Evidence and speculations: vaccines and therapeutic options for COVID-19 pandemic

被引：2
作者：
Siddique, Rabeea [1 ,2 ]
Bai, Qian [1 ,2 ]
Shereen, Muhammad Adnan [3 ]
Nabi, Ghulam [4 ]
Han, Guang [5 ]
Rashid, Farooq [6 ]
Ahmed, Saeed [1 ,2 ]
Benzhanova, Aigerim [1 ]
Xue, Mengzhou [1 ,2 ]
Khan, Suliman [1 ,2 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 2, Dept Cerebrovasc Dis, Zhengzhou, Peoples R China
[2] Henan Med Key Lab Translat Cerebrovasc Dis, Zhengzhou, Peoples R China
[3] Wuhan Univ, Coll Life Sci, State Key Lab Virol, Wuhan, Peoples R China
[4] Hebei Normal Univ, Coll Life Sci, Key Lab Anim Physiol Biochem & Mol Biol Hebei Pro, State Key Lab Virol, Shijiazhuang, Hebei, Peoples R China
[5] Huazhong Univ Sci & Technol, Tongji Med Coll, Hubei Canc Hosp, Dept Radiat Oncol, Wuhan, Peoples R China
[6] Southern Med Univ, Dept Epidemiol, Sch Publ Hlth, Guangzhou, Peoples R China
来源：
HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2021年 / 17卷 / 04期
基金：
中国国家自然科学基金;
关键词：
SARS-CoV-2; covid-19; genome; therapeutic options; vaccine development; human health; CORONAVIRUS; SUBUNIT; ORIGIN; HEALTH; SPIKE;
D O I：
10.1080/21645515.2020.1824497
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A novel coronavirus (2019-nCov) emerged in China, at the end of December 2019 which posed an International Public Health Emergency, and later declared as a global pandemic by the World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) named it SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus-2), while the disease was named COVID-19 (Coronavirus Disease- 2019). Many questions related to the exact mode of transmission, animal origins, and antiviral therapeutics are not clear yet. Nevertheless, it is required to urgently launch a new protocol to evaluate the side effects of unapproved vaccines and antiviral therapeutics to accelerate the clinical application of new drugs. In this review, we highlight the most salient characteristics and recent findings of COVID-19 disease, molecular virology, interspecies mechanisms, and health consequences related to this disease.
引用
收藏
页码：1113 / 1121
页数：9
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