One-pot fluorination and asymmetric Michael addition promoted by recyclable fluorous organocatalysts

被引：25

作者：

Yi, Wen-Bin ^{[1
]}

Zhang, Zijuan ^{[2
]}

Huang, Xin ^{[2
]}

Tanner, Angela ^{[2
]}

Cai, Chun ^{[1
]}

Zhang, Wei ^{[2
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

[2] Univ Massachusetts, Dept Chem, Boston, MA 02125 USA

来源：

RSC ADVANCES | 2013年 / 3卷 / 40期

基金：

中国国家自然科学基金;

关键词：

ENANTIOSELECTIVE CONJUGATE ADDITION; DIELS-ALDER REACTIONS; NITROALKENES; CHALCONES; CARBONYL; MALONATE; KETONES; UREA;

D O I：

10.1039/c3ra42501k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel one-pot fluorination and asymmetric Michael addition reaction sequence promoted by recyclable fluorous bifunctional cinchona alkaloid-thiourea organocatalysts is introduced for the synthesis of alpha-fluoro-beta-ketoesters bearing two chiral centers.

引用

页码：18267 / 18270

页数：4

共 43 条

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Zhang, Wei
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[43] Enantioselective organocatalytic fluorination using organofluoro nucleophiles
Zhao, Yujun
Pan, Yuanhang
Sim, Sui-Boon Derek
Tan, Choon-Hong
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (03) : 479 - 485

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