New and Future Drug Development for Gastroesophageal Reflux Disease

被引：52

作者：

Maradey-Romero, Carla ^{[1
]}

Fass, Ronnie ^{[1
]}

机构：

[1] Case Western Reserve Univ, Metrohlth Med Ctr, Div Gastroenterol & Hepatol, Esophageal & Swallowing Ctr, Cleveland, OH USA

来源：

JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY | 2014年 / 20卷 / 01期

关键词：

Erosive esophagitis; Gastroesophageal reflux; Heartburn; Proton pump inhibitors; PROTON-PUMP INHIBITOR; ESOPHAGEAL SPHINCTER RELAXATIONS; COMPETITIVE ACID BLOCKER; DELAYED-RELEASE FORMULATION; RANDOMIZED CLINICAL-TRIAL; DOUBLE-BLIND; DEXLANSOPRAZOLE MR; ENDOGENOUS CHOLECYSTOKININ; ARBACLOFEN PLACARBIL; EROSIVE ESOPHAGITIS;

D O I：

10.5056/jnm.2014.20.1.6

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Medical therapy remains the most popular treatment for gastroesophageal reflux disease (GERD). Whilst interest in drug development for GERD has declined over the last few years primarily due to the conversion of most proton pump inhibitor (PPI)'s to generic and over the counter compounds, there are still numerous areas of unmet needs in GERD. Drug development has been focused on potent histamine type 2 receptor antagonist's, extended release PPI's, PPI combination, potassium-competitive acid blockers, transient lower esophageal sphincter relaxation reducers, prokinetics, mucosal protectants and esophageal pain modulators. It is likely that the aforementioned compounds will be niched for specific areas of unmet need in GERD, rather than compete with the presently available anti-reflux therapies.

引用

页码：6 / 16

页数：11

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