Enones from Acid Fluorides and Vinyl Triflates by Reductive Nickel Catalysis

被引：53

作者：

Pan, Feng-Feng ^{[1
]}

Guo, Peng ^{[1
]}

Li, Chun-Ling ^{[1
]}

Su, Peifeng ^{[1
]}

Shu, Xing-Zhong ^{[1
]}

机构：

[1] Lanzhou Univ, Coll Chem & Chem Engn, SKLAOC, 222 South Tianshui Rd, Lanzhou 730000, Gansu, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 10期

基金：

中国国家自然科学基金;

关键词：

CROSS-COUPLING REACTIONS; ALKYL-HALIDES; CARBOXYLIC-ACIDS; KETONE FORMATION; ACYL FLUORIDES; ARYL; CHLORIDES; REAGENTS; IODIDES; ELECTROPHILES;

D O I：

10.1021/acs.orglett.9b01164

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A nickel-catalyzed reductive coupling between acid fluorides and vinyl triflates has been described. This method provides an efficient access to various enones and avoids the requirement for acyl or vinyl metallic reagents in the conventional approaches. The reaction proceeds with a broad range of acid fluorides and cyclic vinyl triflates, tolerating several functional groups. The utility of this synthetic method has been demonstrated by the late-stage modification of pharmaceuticals and biologically active natural compounds.

引用

页码：3701 / 3705

页数：5

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