The discovery of a novel orally available CCR5 antagonist, as a therapeutic for HIV-1 infection

被引:0
作者
Nogi, Rena Nishizawa
Nishiyama, Toshihiko
Hisaichi, Katsuya
Minamoto, Chiaki
Matsunaga, Naoki
Hirai, Keisuke
Habashita, Hiromu
Takaoka, Yoshikazu
Toda, Masaaki
Takahashi, Eiji
Imawaka, Haruo
Sagawa, Kenji
Shibayama, Shiro
Fukushima, Daikichi
Maeda, Kenji
Mitsuya, Hiroaki
机构
[1] ONO PHARMACEUT CO LTD, Dept Med Chem, Mishima, Osaka 6188585, Japan
[2] ONO PHARMACEUT CO LTD, Pharmacokinet Res Labs, Mishima, Osaka 6188585, Japan
来源
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 231卷
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
385-MEDI
引用
收藏
页数:1
相关论文
共 50 条
[31]   Discovery of potent, selective and orally active CCR5 antagonists for the potential treatment of HIV infection. [J].
Tagat, J ;
McCombie, S ;
Nazareno, D ;
Steensma, R ;
Labroli, M ;
Baroudy, B ;
Strizki, J ;
Cox, K .
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 225 :U175-U175
[32]   CCR5 and HIV infection [J].
Blanpain, C ;
Libert, F ;
Vassart, G ;
Parmentier, M .
RECEPTORS & CHANNELS, 2002, 8 (01) :19-31
[33]   Mechanism of transdominant inhibition of CCR5-mediated HIV-1 infection by ccr5Δ32 [J].
Benkirane, M ;
Jin, DY ;
Chun, RF ;
Koup, RA ;
Jeang, KT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30603-30606
[34]   CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia [J].
Jianglin He ;
Youzhi Chen ;
Michael Farzan ;
Hyeryun Choe ;
Asa Ohagen ;
Suzanne Gartner ;
Jorge Busciglio ;
Xiaoyu Yang ;
Wolfgang Hofmann ;
Walter Newman ;
Charles R. Mackay ;
Joseph Sodroski ;
Dana Gabuzda .
Nature, 1997, 385 :645-649
[35]   CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia [J].
He, JL ;
Chen, YZ ;
Farzan, M ;
Choe, HY ;
Ohagen, A ;
Gartner, S ;
Busciglio, J ;
Yang, XY ;
Hofmann, W ;
Newman, W ;
Mackay, CR ;
Sodroski, J ;
Gabuzda, D .
NATURE, 1997, 385 (6617) :645-649
[36]   Evolution of CCR5 Antagonist Resistance in an HIV-1 Subtype C Clinical Isolate [J].
Henrich, Timothy J. ;
Tsibris, Athe M. N. ;
Lewine, Nicolas R. P. ;
Konstantinidis, Ioannis ;
Leopold, Kay E. ;
Sagar, Manish ;
Kuritzkes, Daniel R. .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2010, 55 (04) :420-427
[37]   CCR5 antagonist-resistant HIV-1 entry kinetics as a function of CD4 and CCR5 surface expression [J].
Putcharoen, O. ;
Lee, S-H ;
Henrich, T. J. ;
Vanichanan, J. ;
Kuritzkes, D. R. ;
Tsibris, A. M. N. .
ANTIVIRAL THERAPY, 2011, 16 :A64-A64
[38]   Effects of CCR2 and CCR5 polymorphisms on HIV-1 infection in Thai females [J].
Wichukchinda, Nuanjun ;
Nakayama, Emi E. ;
Rojanawiwat, Archawin ;
Pathipvanich, Panita ;
Auwanit, Rattana ;
Vongsheree, Suthon ;
Ariyoshi, Koya ;
Sawanpanyalert, Pathom ;
Shioda, Tatsuo .
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2008, 47 (03) :293-297
[39]   Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity [J].
Xue, Chu-Biao ;
Chen, Lihua ;
Cao, Ganfeng ;
Zhang, Ke ;
Wang, Anlai ;
Meloni, David ;
Glenn, Joseph ;
Anand, Rajan ;
Xia, Michael ;
Kong, Ling ;
Huang, Taisheng ;
Feng, Hao ;
Zheng, Changsheng ;
Li, Mei ;
Galya, Laurine ;
Zhou, Jiacheng ;
Shin, Niu ;
Baribaud, Fredric ;
Solomon, Kim ;
Scherle, Peggy ;
Zhao, Bitao ;
Diamond, Sharon ;
Emm, Tom ;
Keller, Douglas ;
Contel, Nancy ;
Yeleswaram, Swamy ;
Vaddi, Kris ;
Hollis, Gregory ;
Newton, Robert ;
Friedman, Steven ;
Metcalf, Brian .
ACS MEDICINAL CHEMISTRY LETTERS, 2010, 1 (09) :483-487
[40]   HIV-1 infection through the CCR5 receptor is blocked by receptor dimerization [J].
Vila-Coro, AJ ;
Mellado, M ;
de Ana, AM ;
Lucas, P ;
del Real, G ;
Martinez, C ;
Rodriguez-Frade, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (07) :3388-3393