Common and divergent functions of Beclin 1 and Beclin 2

被引：9

作者：

Galluzzi, Lorenzo ^{[1
,2
,3
]}

Kroemer, Guido ^{[2
,3
,4
,5
,6
]}

机构：

[1] Gustave Roussy, Villejuif, France

[2] Univ Paris 05, Sorbonne Paris Cite, Paris, France

[3] Ctr Rech Cordeliers, Equipe Labellisee Ligue Natl Canc 11, Paris, France

[4] INSERM, U848, Villejuif, France

[5] Hop Europeen Georges Pompidou, AP HP, Pole Biol, Paris, France

[6] Gustave Roussy, Metabol & Cell Biol Platforms, Villejuif, France

来源：

CELL RESEARCH | 2013年 / 23卷 / 12期

关键词：

AUTOPHAGY;

D O I：

10.1038/cr.2013.129

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In a recent paper published in Cell, He and colleagues reported the identification and functional characterization of Beclin 2, a mammalspecific homolog of the evolutionarily conserved autophagy-regulatory and oncosuppressive factor Beclin 1. In spite of a non-negligible degree of sequence identity, Beclin 1 and Beclin 2 differ from each other in multiple aspects, including their functional profile as well as the genomic organization of the respective loci.

引用

收藏

页码：1341 / 1342

页数：2

相关论文

共 10 条

[1]

Choi AMK, 2013, NEW ENGL J MED, V368, P1845, DOI [10.1056/NEJMra1205406, 10.1056/NEJMc1303158]

[2] The Beclin 1-VPS34 complex - at the crossroads of autophagy and beyond [J].

Funderburk, Sarah F. ;

Wang, Qing Jun ;

Yue, Zhenyu .

TRENDS IN CELL BIOLOGY, 2010, 20 (06) :355-362

[3] Mitochondria and the Autophagy-Inflammation-Cell Death Axis in Organismal Aging [J].

Green, Douglas R. ;

Galluzzi, Lorenzo ;

Kroemer, Guido .

SCIENCE, 2011, 333 (6046) :1109-1112

[4] Beclin 2 Functions in Autophagy, Degradation of G Protein-Coupled Receptors, and Metabolism [J].

He, Congcong ;

Wei, Yongjie ;

Sun, Kai ;

Li, Binghua ;

Dong, Xiaonan ;

Zou, Zhongju ;

Liu, Yang ;

Kinch, Lisa N. ;

Khan, Shaheen ;

Sinha, Sangita ;

Xavier, Ramnik J. ;

Grishin, Nick V. ;

Xiao, Guanghua ;

Eskelinen, Eeva-Liisa ;

Scherer, Philipp E. ;

Whistler, Jennifer L. ;

Levine, Beth .

CELL, 2013, 154 (05) :1085-1099

[5] Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis [J].

He, Congcong ;

Bassik, Michael C. ;

Moresi, Viviana ;

Sun, Kai ;

Wei, Yongjie ;

Zou, Zhongju ;

An, Zhenyi ;

Loh, Joy ;

Fisher, Jill ;

Sun, Qihua ;

Korsmeyer, Stanley ;

Packer, Milton ;

May, Herman I. ;

Hill, Joseph A. ;

Virgin, Herbert W. ;

Gilpin, Christopher ;

Xiao, Guanghua ;

Bassel-Duby, Rhonda ;

Scherer, Philipp E. ;

Levine, Beth .

NATURE, 2012, 481 (7382) :511-U126

[6] Autophagy and the Integrated Stress Response [J].

Kroemer, Guido ;

Marino, Guillermo ;

Levine, Beth .

MOLECULAR CELL, 2010, 40 (02) :280-293

[7] Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein [J].

Liang, XH ;

Kleeman, LK ;

Jiang, HH ;

Gordon, G ;

Goldman, JE ;

Berry, G ;

Herman, B ;

Levine, B .

JOURNAL OF VIROLOGY, 1998, 72 (11) :8586-8596

[8] The Endocannabinoid System and Its Relevance for Nutrition [J].

Maccarrone, Mauro ;

Gasperi, Valeria ;

Catani, Maria Valeria ;

Diep, Thi Ai ;

Dainese, Enrico ;

Hansen, Harald S. ;

Avigliano, Luciana .

ANNUAL REVIEW OF NUTRITION, VOL 30, 2010, 30 :423-440

[9] The autophagy effector Beclin 1: a novel BH3-only protein [J].

Sinha, S. ;

Levine, B. .

ONCOGENE, 2008, 27 (Suppl 1) :S137-S148

[10] Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor [J].

Yue, ZY ;

Jin, SK ;

Yang, CW ;

Levine, AJ ;

Heintz, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (25) :15077-15082