The innervation of outer hair cells: 3D reconstruction from TEM serial sections in the Japanese macaque

被引:17
作者
Sato, M
Henson, MM
Henson, OW
Smith, DW
机构
[1] Duke Univ, Med Ctr, Div Otolaryngol Head & Neck Surg, Hearing Res Labs, Durham, NC 27710 USA
[2] Natl Def Med Coll, Dept Otolaryngol Head & Neck Surg, Tokorozawa, Saitama 359, Japan
[3] Univ N Carolina, Div Otolaryngol Head & Neck Surg, Chapel Hill, NC USA
[4] Univ N Carolina, Dept Cell Biol & Anat, Chapel Hill, NC USA
关键词
outer hair cell; synapse; organ of corti; Japanese macaque; three-dimensional reconstruction; innervation;
D O I
10.1016/S0378-5955(99)00086-6
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Transmission electron micrographs from serial sections were obtained from the neural pole of outer hair cells (OHCs) in the Japanese macaque (Macaca fuscata) and reconstructions of nerve terminals were made using computer software. Data are based on observations of six cells in the basal turn, eight in the middle turn and four in the apex. In general, the number of afferent (type II) terminals on each OHC increased from base to apex, and for a given turn, the numbers appeared unrelated to OHC row. On the other hand, the number of efferent terminals was greater in the middle turn than in other areas, and the number decreased from row 1 to row 3. Reciprocal synapses increased in frequency from the upper basal turn apicalward. The total number of terminals synapsing on an individual OHC increased from base to apex by nearly 100%. Three-dimensional reconstructions showed that nerve fibers terminating on basal and middle turn OHCs ascended directly from sub-OHC regions to synapse on the subnuclear regions of the OHC. In contrast, apical turn fibers ran horizontally at the level of the subnuclear region and the terminals appeared as en passant swellings along a single fiber. Although physiological data are wanting for the macaque, the anatomical findings suggest that functional differences may exist along the length of the cochlea. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:29 / 38
页数:10
相关论文
共 32 条
[1]  
ADES HW, 1974, AUDITORY SYSTEM ANAT, P125
[2]  
BISHOP AL, 1998, ANIMAL SONAR, P307
[3]   INNERVATION OF ORGAN OF CORTI - SCANNING ELECTRON-MICROSCOPIC STUDY [J].
BREDBERG, G .
ACTA OTO-LARYNGOLOGICA, 1977, 83 (1-2) :71-78
[4]  
BROWN MC, 1988, HEAR RES, V40, P93
[5]   EFFECT OF CONTRALATERAL AUDITORY-STIMULI ON ACTIVE COCHLEAR MICROMECHANICAL PROPERTIES IN HUMAN-SUBJECTS [J].
COLLET, L ;
KEMP, DT ;
VEUILLET, E ;
DUCLAUX, R ;
MOULIN, A ;
MORGON, A .
HEARING RESEARCH, 1990, 43 (2-3) :251-262
[6]  
Dolan D F., 1994, A.R.O. Abstracts, P89
[7]   TOPOGRAPHIC ORGANIZATION OF THE OLIVOCOCHLEAR PROJECTIONS FROM THE LATERAL AND MEDIAL ZONES OF THE SUPERIOR OLIVARY COMPLEX [J].
GUINAN, JJ ;
WARR, WB ;
NORRIS, BE .
JOURNAL OF COMPARATIVE NEUROLOGY, 1984, 226 (01) :21-27
[8]   EFFECTS OF ELECTRICAL-STIMULATION OF EFFERENT OLIVOCOCHLEAR NEURONS ON CAT AUDITORY-NERVE FIBERS .1. RATE-LEVEL FUNCTIONS [J].
GUINAN, JJ ;
GIFFORD, ML .
HEARING RESEARCH, 1988, 33 (02) :97-113
[9]  
GUINAN JJ, 1997, COCHLEA, P435
[10]   COMPUTER-AIDED 3-DIMENSIONAL RECONSTRUCTION AND MORPHOMETRY OF THE OUTER HAIR-CELLS OF THE GUINEA-PIG COCHLEA [J].
HASHIMOTO, S ;
KIMURA, RS .
ACTA OTO-LARYNGOLOGICA, 1988, 105 (1-2) :64-74