Pulmonary function in ankylosing spondylitis: association with clinical variables

被引：12

作者：

Brambila-Tapia, A. J. L. ^{[1
,2
]}

Rocha-Munoz, A. D. ^{[3
,4
]}

Gonzalez-Lopez, L. ^{[4
,5
]}

Vazquez-Del-Mercado, M. ^{[6
]}

Salazar-Paramo, M. ^{[7
,8
]}

Davalos-Rodriguez, I. P. ^{[1
,2
]}

De la Cerda-Trujillo, L. ^{[4
,7
]}

Diaz-Toscano, M. L. ^{[4
,7
]}

Hernandez-Cuervo, P. ^{[7
]}

Diaz-Rizo, V. ^{[7
,9
]}

Sanchez-Mosco, D. ^{[5
,9
]}

Vazquez-Jimenez, J. C. ^{[9
]}

Cardona-Munoz, E. G. ^{[4
]}

Gamez-Nava, J. I. ^{[4
,7
]}

机构：

[1] IMSS, Ctr Invest Biomed Occidente, Guadalajara, Jalisco, Mexico

[2] Univ Guadalajara, CUCS, Inst Genet Humana, Guadalajara 44430, Jalisco, Mexico

[3] Consejo Nacl Ciencia & Tecnol CONACYT, Programa Nacl Postdoctorado, Guadalajara, Jalisco, Mexico

[4] Univ Guadalajara, CUCS, Guadalajara 44430, Jalisco, Mexico

[5] IMSS, Hosp Gen Reg 110, Guadalajara, Jalisco, Mexico

[6] Univ Guadalajara, Inst Invest Reumatol & Sistema Musculoesquelet, CUCS, Guadalajara 44430, Jalisco, Mexico

[7] Inst Mexicano Seguro Social, Hosp Especialidades Ctr Med Nacl Occidente, Unidad Invest Epidemiol Clin, Guadalajara, Jalisco, Mexico

[8] Univ Guadalajara, Dept Fisiol, Ctr Univ Ciencias Salud, Guadalajara 44430, Jalisco, Mexico

[9] Univ Colima, Ctr Univ Invest Biomed, Colima, Mexico

来源：

RHEUMATOLOGY INTERNATIONAL | 2013年 / 33卷 / 09期

关键词：

Spondyloarthritis; Pulmonary function tests; Disease activity; Functioning; Anti-TNF agents; EXERCISE TOLERANCE; CHEST EXPANSION; FUNCTION TESTS; INVOLVEMENT;

D O I：

10.1007/s00296-013-2723-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To evaluate the association between pulmonary function and clinical variables in ankylosing spondylitis (AS) and to compare the pulmonary function of patients with AS with that of healthy controls, 61 AS patients and 74 healthy controls were included. In AS, we assessed clinical disease indices (BASDAI, BASFI, BASG), morning stiffness, number of hypersensitive entheses, metrology measures, 6-min walking test, acute phase reactants, radiological presence of "bamboo spine," and severity of radiological involvement in sacroiliac and vertebral joints. AS and healthy controls had similar age and gender. All the parameters of pulmonary function were significantly diminished in AS than in healthy controls (p < 0.001), with a higher proportion of restrictive pattern (57.4 vs. 5.4 %). In AS, pulmonary function correlated negatively with BASDAI, BASFI, BASG, morning stiffness, number of hypersensitive entheses, occiput-wall distance, and ESR, and positively with 6-min walking test. There was no association between pulmonary function with radiological stage of vertebral joints and sacroiliac joints, "bamboo spine," disease duration, or chest expansion. A higher frequency of AS patients had a decreased pulmonary function and results of the 6-min walking test. These abnormalities in AS were more related with disease activity than with mobility limitation.

引用

页码：2351 / 2358

页数：8

共 20 条

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