Copper-catalyzed synthesis of α,β-unsaturated acylamides via direct amidation from cinnamic acids and N-substituted formamides

被引：14

作者：

Yan, Hong ^{[1
]}

Yang, Hailong ^{[1
]}

Lu, Linhua ^{[1
]}

Liu, Defu ^{[1
]}

Rong, Guangwei ^{[1
]}

Mao, Jincheng ^{[1
]}

机构：

[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

TETRAHEDRON | 2013年 / 69卷 / 35期

关键词：

Amidation; Cinnamamide; N-Substituted formamide; Ligand-free; Cinnamic acid; MONOXIDE-FREE AMINOCARBONYLATION; ASYMMETRIC EPOXIDATION; AMIDES; ARYL; DERIVATIVES; CYCLIZATION; GENERALIST; EFFICIENT; RADICALS; ALPHA;

D O I：

10.1016/j.tet.2013.06.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly effective synthesis of alpha,beta-unsaturated acylamides is reported for the first time via copper-catalyzed direct amidation between readily available cinnamic acids and N-substituted formamides. The protocol was easily accessible and practical. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：7258 / 7263

页数：6

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