Copper-catalyzed synthesis of α,β-unsaturated acylamides via direct amidation from cinnamic acids and N-substituted formamides

被引：14
|
作者：
Yan, Hong [1 ]
Yang, Hailong [1 ]
Lu, Linhua [1 ]
Liu, Defu [1 ]
Rong, Guangwei [1 ]
Mao, Jincheng [1 ]
机构：
[1] Soochow Univ, Key Lab Organ Synth Jiangsu Prov, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China
来源：
TETRAHEDRON | 2013年 / 69卷 / 35期
关键词：
Amidation; Cinnamamide; N-Substituted formamide; Ligand-free; Cinnamic acid; MONOXIDE-FREE AMINOCARBONYLATION; ASYMMETRIC EPOXIDATION; AMIDES; ARYL; DERIVATIVES; CYCLIZATION; GENERALIST; EFFICIENT; RADICALS; ALPHA;
D O I：
10.1016/j.tet.2013.06.078
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly effective synthesis of alpha,beta-unsaturated acylamides is reported for the first time via copper-catalyzed direct amidation between readily available cinnamic acids and N-substituted formamides. The protocol was easily accessible and practical. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7258 / 7263
页数：6
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