Rational design of near-infrared platinum(ii)-acetylide conjugated polymers for photoacoustic imaging-guided synergistic phototherapy under 808 nm irradiation

被引:15
作者
Li, Guo [1 ,2 ]
Hu, Wenbo [1 ,2 ]
Zhao, Menglong [1 ,2 ]
Zhao, Weili [1 ,2 ]
Li, Feiyang [1 ,2 ]
Liu, Shujuan [1 ,2 ]
Huang, Wei [1 ,2 ]
Zhao, Qiang [1 ,2 ]
机构
[1] Nanjing Univ Pasts & Telecommun NUPT, Inst Adv Mat IAM, Key Lab Organ Elect & Informat Displays, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
[2] Nanjing Univ Pasts & Telecommun NUPT, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, 9 Wenyuan Rd, Nanjing 210023, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
HIGHLY EFFICIENT; PHOTODYNAMIC THERAPY; NANOPARTICLES; FLUORESCENCE; NANOMATERIALS; LUMINESCENCE; CHEMOTHERAPY; DOTS;
D O I
10.1039/d0tb01107j
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The preferable photoconversion tunability of conjugated polymers (CPs) is of great interest in cancer phototherapy. However, very few molecular design strategies have been developed for achieving CPs with highly efficient photoconversion performance. Herein, a rational design of near-infrared (NIR) Pt-acetylide conjugated polymerCP3with highly efficient photoconversion behaviors for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) was demonstrated.CP3containing boron dipyrromethene (BDP) units displayed intense absorption peaks in the NIR region, which were red-shifted approximately 60 nm compared to the corresponding small-molecule precursor of BDP. Compared with control polymersCP1andCP2, after the introduction of Pt intoCP3, the triplet state, which benefits the generation of reactive oxygen species for photodynamic therapy, was identified clearly in bothCP3and the preparedCP3nanoparticles (CP3-NPs) by ultrafast femtosecond transient absorption (fs-TA) spectroscopy. Notably, different from the traditional nonradiative decay channel with lifetime of 1.1 ps inCP3,CP3-NPs possess an additional nonradiative decay channel with lifetime of 10 ps, both of which contribute to the superior photothermal conversion effect upon 808 nm irrradiation. All these photoconversion performances lead to excellent tumor ablation. This study elucidates the excited-state dynamics in Pt-acetylide CPs, which provide an insightful understanding and valuable guidelines for the future design of high-performance theranostic agents based on CPs for synergistic cancer phototherapy.
引用
收藏
页码:7356 / 7364
页数:9
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