Clinical outcomes of patients treated using very short duration dual antiplatelet therapy after implantation of biodegradable-polymer drug-eluting stents: rationale and design of a prospective multicenter REIWA registry

被引：7

作者：

Ishida, Masaru ^{[1
]}

Takahashi, Fumiaki ^{[2
]}

Goto, Iwao ^{[1
]}

Niiyama, Masanobu ^{[3
]}

Saitoh, Hidenori ^{[4
]}

Sakamoto, Tsubasa ^{[5
]}

Maegawa, Yuko ^{[6
]}

Osaki, Takuya ^{[7
]}

Nishiyama, Osamu ^{[8
]}

Endo, Hiroshi ^{[9
]}

Sakamoto, Ryohei ^{[10
]}

Kojima, Tsuyoshi ^{[11
]}

Koeda, Yorihiko ^{[1
]}

Kimura, Takumi ^{[1
]}

Itoh, Tomonori ^{[1
]}

Morino, Yoshihiro ^{[1
]}

机构：

[1] Iwate Med Univ, Div Cardiol, Dept Internal Med, 2-1-1 Idaidori, Yahaba, Iwate 0203695, Japan

[2] Iwate Med Univ, Dept Informat Sci, Div Med Engn, Yahaba, Iwate, Japan

[3] Hachinohe Red Cross Hosp, Dept Cardiol, Hachinohe, Aomori, Japan

[4] Iwate Prefectural Ofunato Hosp, Dept Cardiol, Kitakami, Iwate, Japan

[5] Iwate Prefectural Ofunato Hosp, Dept Cardiol, Ofunato, Japan

[6] Iwate Prefectural Miyako Hosp, Dept Cardiol, Miyako, Japan

[7] Iwate Prefectural Kuji Hosp, Dept Cardiol, Kuji, Japan

[8] Iwate Prefectural Ninohe Hosp, Dept Cardiol, Ninohe, Japan

[9] Iwate Prefectural Iwai Hosp, Dept Cardiol, Ichinoseki, Japan

[10] Nakadori Gen Hosp, Dept Cardiol, Akita, Japan

[11] Morioka Red Cross Hosp, Dept Cardiol, Morioka, Iwate, Japan

来源：

CARDIOVASCULAR INTERVENTION AND THERAPEUTICS | 2020年 / 35卷 / 04期

关键词：

Coronary artery disease; Drug-eluting stent; Dual antiplatelet therapy; Percutaneous coronary intervention; CORONARY; TRIAL; EVENTS; CLOPIDOGREL; THROMBOSIS; COVERAGE; SYSTEM; RISK; THIN; PCI;

D O I：

10.1007/s12928-020-00694-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several studies have demonstrated the safety and feasibility of short (3-6 months) and very short duration (< 2 months) dual antiplatelet therapy (DAPT) in patients with a durable-polymer drug-eluting stent (DP-DES). However, the clinical importance of using very short duration DAPT has yet to be established in patients with a biodegradable polymer drug-eluting stent (BP-DES). The aim of this REIWA registry (multicenter and prospective registry; investigation of clinical outcomes of patients treated with short duration dual antiplatelet therapy after implantation of biodresorbable-polymer drug-eluting stent: a multicenter, prospective registry from Iwate medical university affiliated hospitals) is to determine the safety and feasibility of using 1-month DAPT followed by P2Y12 inhibitor monotherapy in patients after BP-DES implantation. This study is an observational, prospective, multicenter registry encompassing the entire local medical region of Iwate Prefecture (northern area of mainland Japan). A total of 1200 patients who underwent successful PCI with a novel thin strut BP-DES (Synergy, Ultimaster or Orsiro) and are considered to be appropriate patients for very short DAPT, are registered and subsequently administered 1-month DAPT followed by P2Y12 inhibitor monotherapy (clopidogrel 75 mg/day or prasugrel 3.75 mg/day). The primary endpoint was a composite of cardiovascular and bleeding events, which included cardiovascular death, spontaneous myocardial infarction, definite stent thrombosis, ischemic or hemorrhagic stroke, or TIMI major or minor bleeding at 12 months. The REIWA registry (UMIN000037321) will demonstrate both the safety and feasibility of using 1-month DAPT in patients with BP-DES. Furthermore, results of this study will also be able to provide supportive evidence for P2Y12 inhibitor monotherapy after 1-month DAPT following BP-DES implantation.

引用

页码：398 / 404

页数：7

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