High RASD1 transcript levels at diagnosis predicted poor survival in adult B-cell acute lymphoblastic leukemia patients

被引:8
作者
Wang, Shujuan [1 ]
Wang, Chong [1 ]
Wang, Weiqiong [1 ]
Hao, Qianqian [1 ]
Liu, Yanfang [1 ]
机构
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Hematol, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China
基金
中国国家自然科学基金;
关键词
Adult B-cell acute lymphoblastic leukemia; RASD1; Prognosis; Proliferation; Drug resistance; GENE; RELAPSE; PROTEIN;
D O I
10.1016/j.leukres.2019.03.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
B-cell acute lymphoblastic leukemia (B-ALL) in adults remains a highly challenging disease. Identifying new prognostic biomarkers is necessary to help select the best therapeutic schedules and to improve prognosis. We performed bioinformatics analyses of transcriptomic data to identify aberrantly-expressed mRNA transcripts in B-ALL and focused on RASD1 (Ras-related dexamethasone-induced 1). To date, no information is available on the prognostic value of RASD1 in B-ALL. Fifty-three consecutive adults with de novo B-ALL were enrolled in this study. Our data suggested that RASD1 was abnormally overexpressed in B-ALL. High RASD1 transcript levels at diagnosis were associated with lower survival probabilities (44% [20%-61%] vs. 79% [60%-97%]; P = 0.037) and were also an independent prognostic factor in adult B-ALL (HR = 4.9 [1.5-15.9]; P = 0.008). Functional in vitro analyses and bioinformatic analyses indicated that RASD1 promoted cell proliferation, cell cycle progression and chemotherapy resistance and inhibited cell apoptosis. These data demonstrated that RASD1 might serve as a novel prognostic biomarker for adult B-ALL and as a potential therapeutic target in adult B-ALL patients.
引用
收藏
页码:26 / 32
页数:7
相关论文
共 24 条
  • [1] Acute Lymphoblastic Leukemia, Version 2.2015
    Alvarnas, Joseph C.
    Brown, Patrick A.
    Aoun, Patricia
    Ballen, Karen Kuhn
    Barta, Stefan K.
    Borate, Uma
    Boyer, Michael W.
    Burke, Patrick W.
    Cassaday, Ryan
    Castro, Januario E.
    Coccia, Peter F.
    Coutre, Steven E.
    Damon, Lloyd E.
    DeAngelo, Daniel J.
    Douer, Dan
    Frankfurt, Olga
    Greer, John P.
    Johnson, Robert A.
    Kantarjian, Hagop M.
    Klisovic, Rebecca B.
    Kupfer, Gary
    Litzow, Mark
    Liu, Arthur
    Rao, Arati V.
    Shah, Bijal
    Uy, Geoffrey L.
    Wang, Eunice S.
    Zelenetz, Andrew D.
    Gregory, Kristina
    Smith, Courtney
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2015, 13 (10): : 1240 - 1279
  • [2] Runx2 transcriptome of prostate cancer cells: insights into invasiveness and bone metastasis
    Baniwal, Sanjeev K.
    Khalid, Omar
    Gabet, Yankel
    Shah, Ruchir R.
    Purcell, Daniel J.
    Mav, Deepak
    Kohn-Gabet, Alice E.
    Shi, Yunfan
    Coetzee, Gerhard A.
    Frenkel, Baruch
    [J]. MOLECULAR CANCER, 2010, 9
  • [3] Oncogenic Properties of Candidate Oncogenes in Chromosome Region 17p11.2p12 in Human Osteosarcoma
    Both, Joeri
    Wu, Thijs
    ten Asbroek, Anneloor L. M. A.
    Baas, Frank
    Hulsebos, Theo J. M.
    [J]. CYTOGENETIC AND GENOME RESEARCH, 2016, 150 (01) : 52 - 59
  • [4] Identification of Novel Candidate Oncogenes in Chromosome Region 17p11.2-p12 in Human Osteosarcoma
    Both, Joeri
    Wu, Thijs
    Bras, Johannes
    Schaap, Gerard R.
    Baas, Frank
    Hulsebos, Theo J. M.
    [J]. PLOS ONE, 2012, 7 (01):
  • [5] Acute Lymphoblastic Leukemia, Version 1.2017 Featured Updates to the NCCN Guidelines
    Brown, Patrick A.
    Shah, Bijal
    Fathi, Amir
    Wieduwilt, Matthew
    Advani, Anjali
    Aoun, Patricia
    Barta, Stefan K.
    Boyer, Michael W.
    Bryan, Teresa
    Burke, Patrick W.
    Cassaday, Ryan
    Coccia, Peter F.
    Coutre, Steven E.
    Damon, Lloyd E.
    DeAngelo, Daniel J.
    Frankfurt, Olga
    Greer, John P.
    Kantarjian, Hagop M.
    Klisovic, Rebecca B.
    Kupfer, Gary
    Litzow, Mark
    Liu, Arthur
    Mattison, Ryan
    Park, Jae
    Rubnitz, Jeffrey
    Saad, Ayman
    Uy, Geoffrey L.
    Wang, Eunice S.
    Gregory, Kristina M.
    Ogba, Ndiya
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (09): : 1091 - 1102
  • [6] Dalgin GS, 2007, CANCER INFORM, V3, P65
  • [7] Standardization and quality control studies of 'real-time' quantitative reverse transcriptase polymerase chain reaction of fusion gene transcripts for residual disease detection in leukemia -: A Europe Against Cancer Program
    Gabert, J
    Beillard, E
    van der Velden, VHJ
    Bi, W
    Grimwade, D
    Pallisgaard, N
    Barbany, G
    Cazzaniga, G
    Cayuela, JM
    Cavé, H
    Pane, F
    Aerts, JLE
    De Micheli, D
    Thirion, X
    Pradel, V
    González, M
    Viehmann, S
    Malec, M
    Saglio, G
    van Dongen, JJM
    [J]. LEUKEMIA, 2003, 17 (12) : 2318 - 2357
  • [8] Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway
    Gao, Shangfeng
    Jin, Lei
    Liu, Guangping
    Wang, Peng
    Sun, Zonghan
    Cao, Yujia
    Shi, Hengliang
    Liu, Xuejiao
    Shi, Qiong
    Zhou, Xiuping
    Yu, Rutong
    [J]. SCIENTIFIC REPORTS, 2017, 7
  • [9] In adults with standard-risk acute lymphoblastic leukemia, the greatest benefit is achieved from a matched sibling allogeneic transplantation in first complete remission, and an autologous transplantation is less effective than conventional consolidation/maintenance chemotherapy in all patients: final results of the International ALL Trial (MRC UKALL XII/ECOG E2993)
    Goldstone, Anthony H.
    Richards, Susan M.
    Lazarus, Hillard M.
    Tallman, Martin S.
    Buck, Georgina
    Fielding, Adele K.
    Burnett, Alan K.
    Chopra, Raj
    Wiernik, Peter H.
    Foroni, Letizia
    Paietta, Elisabeth
    Litzow, Mark R.
    Marks, David I.
    Durrant, Jill
    McMillan, Andrew
    Franklin, Ian M.
    Luger, Selina
    Ciobanu, Niculae
    Rowe, Jacob M.
    [J]. BLOOD, 2008, 111 (04) : 1827 - 1833
  • [10] Dexamethasone rapidly induces a novel Ras superfamily member-related gene in AtT-SO cells
    Kemppainen, RJ
    Behrend, EN
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (06) : 3129 - 3131