An efficient conversion of nitriles to amides:: application in the synthesis of N,N-diethyl-m-toluamide (DEET™)

被引：10

作者：

Bhattacharya, A ^{[1
]}

Plata, RE

Villarreal, V

Muramulla, S

Wu, HJ

机构：

[1] Texas A&M Univ, Dept Chem, Kingsville, TX 78363 USA

[2] J&J Pharmaceut Res & Dev LLC, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 04期

关键词：

D O I：

10.1016/j.tetlet.2005.11.063

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Arylnitriles react with magnesium amides to produce carboxamides in excellent yield. The method was applied for the preparation of the insect repellent DEET (TM). (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：505 / 506

页数：2

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