Multifunctional Non-Viral Delivery Systems Based on Conjugated Polymers

被引：26
作者：
Yang, Gaomai [1 ]
Lv, Fengting [1 ]
Wang, Bing [1 ]
Liu, Libing [1 ]
Yang, Qiong [1 ]
Wang, Shu [1 ]
机构：
[1] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China
来源：
MACROMOLECULAR BIOSCIENCE | 2012年 / 12卷 / 12期
基金：
中国国家自然科学基金;
关键词：
biological applications of polymers; conjugated polymers; imaging; non-viral delivery systems; synthesis; DRUG-DELIVERY; ENERGY-TRANSFER; QUANTUM-DOT; MOLECULAR RECOGNITION; ANTICANCER ACTIVITY; GENE DELIVERY; NANOPARTICLES; THERAPY; CELLS; POLYELECTROLYTES;
D O I：
10.1002/mabi.201200267
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Multifunctional nanomaterials with simultaneous therapeutic and imaging functions explore new strategies for the treatment of various diseases. Conjugated polymers (CPs) are considered as novel candidates to serve as multifunctional delivery systems due to their high fluorescence quantum yield, good photostability, and low cytotoxicity. Highly sensitive sensing and imaging properties of CPs are well reviewed, while the applications of CPs as delivery systems are rarely covered. This feature article mainly focuses on CP-based multifunctional non-viral delivery systems for drug, protein, gene, and cell delivery. Promising directions for the further development of CP-based delivery systems are also discussed.
引用
收藏
页码：1600 / 1614
页数：15
相关论文
共 68 条
  • [1] Bacteria-mediated delivery of nanoparticles and cargo into cells
    Akin, Demir
    Sturgis, Jennifer
    Ragheb, Kathy
    Sherman, Debby
    Burkholder, Kristin
    Robinson, J. Paul
    Bhunia, Arun K.
    Mohammed, Sulma
    Bashir, Rashid
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (07) : 441 - 449
  • [2] [Anonymous], SYNTH MET
  • [3] Quantum dot - Aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on Bi-fluorescence resonance energy transfer
    Bagalkot, Vaishali
    Zhang, Liangfang
    Levy-Nissenbaum, Etgar
    Jon, Sangyong
    Kantoff, Philip W.
    Langer, Robert
    Farokhzad, Omid C.
    [J]. NANO LETTERS, 2007, 7 (10) : 3065 - 3070
  • [4] Conjugated polythiophene probes target lysosome-related acidic vacuoles in cultured primary cells
    Bjork, Per
    Nilsson, K. Peter R.
    Lenner, Liselotte
    Kagedal, Bertil
    Persson, Birgitta
    Inganas, Olle
    Jonasson, Jon
    [J]. MOLECULAR AND CELLULAR PROBES, 2007, 21 (5-6) : 329 - 337
  • [5] Polymer-drug conjugates as nano-sized medicines
    Canal, Fabiana
    Sanchis, Joaquin
    Vicent, Maria J.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2011, 22 (06) : 894 - 900
  • [6] Synthesis and Characterization of Degradable Water-Soluble Fluorescent Polymers
    Chong, Hui
    Duan, Xinrui
    Yang, Qiong
    Liu, Libing
    Wang, Shu
    [J]. MACROMOLECULES, 2010, 43 (24) : 10196 - 10200
  • [7] Conjugated Polyelectrolyte Capsules: Light-Activated Antimicrobial Micro "Roach Motels"
    Corbitt, Thomas S.
    Sommer, Jonathan R.
    Chemburu, Sireesha
    Ogawa, Katsu
    Ista, Linnea K.
    Lopez, Gabriel P.
    Whitten, David G.
    Schanze, Kirk S.
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2009, 1 (01) : 48 - 52
  • [8] Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    Curiel, TJ
    Wei, S
    Dong, HD
    Alvarez, X
    Cheng, P
    Mottram, P
    Krzysiek, R
    Knutson, KL
    Daniel, B
    Zimmermann, MC
    David, O
    Burow, M
    Gordon, A
    Dhurandhar, N
    Myers, L
    Berggren, R
    Hemminki, A
    Alvarez, RD
    Emilie, D
    Curiel, DT
    Chen, LP
    Zou, WP
    [J]. NATURE MEDICINE, 2003, 9 (05) : 562 - 567
  • [9] Conjugated polyelectrolyte-cisplatin complex nanoparticles for simultaneous in vivo imaging and drug tracking
    Ding, Dan
    Li, Kai
    Zhu, Zhenshu
    Pu, Kan-Yi
    Hu, Yong
    Jiang, Xiqun
    Liu, Bin
    [J]. NANOSCALE, 2011, 3 (05) : 1997 - 2002
  • [10] The dawning era of polymer therapeutics
    Duncan, R
    [J]. NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) : 347 - 360
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