Probiogenomics as a tool to obtain genetic insights into adaptation of probiotic bacteria to the human gut

被引：60

作者：

Ventura, Marco ^{[1
]}

Turroni, Francesca ^{[1
]}

van Sinderen, Douwe ^{[2
,3
]}

机构：

[1] Univ Parma, Dept Genet Biol Microorganisms Anthropol & Evolut, Lab Probiogenom, I-43100 Parma, Italy

[2] Natl Univ Ireland, Biosci Inst, Alimentary Pharmabiot Ctr, Cork, Ireland

[3] Natl Univ Ireland, Biosci Inst, Dept Microbiol, Cork, Ireland

来源：

BIOENGINEERED | 2012年 / 3卷 / 02期

关键词：

genomics; lactobacilli; probiotic bacteria; gut microbiota; bifidobacteria;

D O I：

10.4161/bbug.18540

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Bifidobacteria and lactobacilli are widely exploited as health-promoting bacteria in many functional foods. However, the molecular mechanisms as to how these bacteria positively impact on host health are far from completely understood. For this reason these microorganisms represent a growing area of interest with respect to their genomics, molecular biology and genetics. Recent genome sequencing of a large number of strains of bifidobacteria and lactobacilli has allowed access to the complete genetic makeup of representative members of these bacteria. Here, we will discuss how the analysis of genomic data has helped us to understand the mechanisms by which these bacteria adapt to the specific environment of the gastrointestinal tract, while also revealing genetic functions that mediate specific host-microbe interactions.

引用

页码：73 / 79

页数：7

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