Anti-HIV-1 nanotherapeutics: promises and challenges for the future

被引：101
作者：
Mahajan, Supriya D. [1 ]
Aalinkeel, Ravikumar [1 ]
Law, Wing-Cheung [2 ]
Reynolds, Jessica L. [1 ]
Nair, Bindukumar B. [1 ]
Sykes, Donald E. [1 ]
Yong, Ken-Tye [4 ]
Roy, Indrajit [3 ]
Prasad, Paras N. [2 ]
Schwartz, Stanley A. [1 ]
机构：
[1] SUNY Buffalo, Dept Med, Div Rheumatol Allergy & Immunol, 444 Innovat Ctr,Buffalo Niagara Med Campus,640 El, Buffalo, NY 14203 USA
[2] SUNY Buffalo, Inst Lasers Photon & Biophoton, Buffalo, NY 14203 USA
[3] Univ Delhi, Dept Chem, Delhi 110007, India
[4] Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore, Singapore
来源：
INTERNATIONAL JOURNAL OF NANOMEDICINE | 2012年 / 7卷
关键词：
nanotherapeutics; HAART; HIV; nano; nanomedicine; drug delivery; BLOOD-BRAIN-BARRIER; HUMAN-IMMUNODEFICIENCY-VIRUS; HIV-1 PROTEASE INHIBITORS; DRUG-DELIVERY; IN-VIVO; ANTIRETROVIRAL DRUG; PEGYLATED IMMUNOLIPOSOMES; POLYMERIC NANOPARTICLES; INTRACELLULAR DELIVERY; QUANTUM DOTS;
D O I：
10.2147/IJN.S25871
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
The advent of highly active antiretroviral therapy (HAART) has significantly improved the prognosis for human immunodeficiency virus (HIV)-infected patients, however the adverse side effects associated with prolonged HAART therapy use continue. Although systemic viral load can be undetectable, the virus remains sequestered in anatomically privileged sites within the body. Nanotechnology-based delivery systems are being developed to target the virus within different tissue compartments and are being evaluated for their safety and efficacy. The current review outlines the various nanomaterials that are becoming increasingly used in biomedical applications by virtue of their robustness, safety, multimodality, and multifunctionality. Nanotechnology can revolutionize the field of HIV medicine by not only improving diagnosis, but also by improving delivery of antiretrovirals to targeted regions in the body and by significantly enhancing the efficacy of the currently available antiretroviral medications.
引用
收藏
页码：5301 / 5314
页数：14
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