In Vivo Tracking Techniques for Cellular Regeneration, Replacement, and Redirection

被引：16

作者：

Aarntzen, Erik H. J. G. ^{[1
,2
,3
]}

Srinivas, Mangala ^{[2
,4
]}

Walczak, Piotr ^{[4
]}

Janowski, Miroslaw ^{[5
,6
]}

Heerschap, Arend ^{[7
]}

de Vries, I. Jolanda M. ^{[2
,3
]}

Figdor, Carl G. ^{[2
]}

Bulte, Jeff W. M. ^{[4
]}

Oyen, Wim J. G. ^{[1
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Nucl Med, NL-6500 HB Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Med Oncol, NL-6500 HB Nijmegen, Netherlands

[4] Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Div MR Res, Baltimore, MD USA

[5] PAS, MMRC, NeuroRepair Dept, Warsaw, Poland

[6] PAS, MMRC, Dept Neurosurg, Warsaw, Poland

[7] Radboud Univ Nijmegen, Med Ctr, Dept Radiol, NL-6500 HB Nijmegen, Netherlands

来源：

JOURNAL OF NUCLEAR MEDICINE | 2012年 / 53卷 / 12期

关键词：

in vivo imaging; tracking; cellular therapy; transplantation; regenerative medicine; DENDRITIC CELLS; STEM-CELLS; GENE; RESPONSES;

D O I：

10.2967/jnumed.112.106146

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Cellular therapy can be defined as the transplantation of living cells for the treatment of medical conditions. Three main objectives of cellular therapy are regeneration of damaged tissue, replacement of function by secretion of biologically active molecules, and redirection of aberrant processes. Given the complex nature of these approaches, in vivo tracking of the transplanted cells is critical to evaluate their potential benefit and to optimize treatment strategies. Recent advances are reviewed that enable in vivo cell tracking as an important adjunct to implement cellular therapy in clinical practice.

引用

页码：1825 / 1828

页数：4

共 24 条

[1] Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3′-fluoro-3′-deoxy-thymidine ([18F]FLT) PET imaging [J].

Aarntzen, Erik H. J. G. ;

Srinivas, Mangala ;

De Wilt, Johannes H. W. ;

Jacobs, Joannes F. M. ;

Lesterhuis, W. Joost ;

Windhorst, Albert D. ;

Troost, Esther G. ;

Bonenkamp, Johannes J. ;

van Rossum, Michelle M. ;

Blokx, Willeke A. M. ;

Mus, Roel D. ;

Boerman, Otto C. ;

Punt, Cornelis J. A. ;

Figdor, Carl G. ;

Oyen, Wim J. G. ;

de Vries, I. Jolanda M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (45) :18396-18399

[2] Adult bone marrow-derived cells for cardiac repair - A systematic review and meta-analysis [J].

Abdel-Latif, Ahmed ;

Bolli, Roberto ;

Tleyjeh, Imad M. ;

Montori, Victor M. ;

Perin, Emerson C. ;

Hornung, Carlton A. ;

Zuba-Surma, Ewa K. ;

Al-Mallah, Mouaz ;

Dawn, Buddhadeb .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (10) :989-997

[3] Obstacles on the way to the clinical visualisation of beta cells: looking for the Aeneas of molecular imaging to navigate between Scylla and Charybdis [J].

Andralojc, K. ;

Srinivas, M. ;

Brom, M. ;

Joosten, L. ;

de Vries, I. J. M. ;

Eizirik, D. L. ;

Boerman, O. C. ;

Meda, P. ;

Gotthardt, M. .

DIABETOLOGIA, 2012, 55 (05) :1247-1257

[4] 111In-oxine and 99mTc-HMPAO labelling of antigen-loaded dendritic cells:: in vivo imaging and influence on motility and actin content [J].

Blocklet, D ;

Toungouz, M ;

Kiss, R ;

Lambermont, M ;

Velu, T ;

Duriau, D ;

Goldman, M ;

Goldman, S .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2003, 30 (03) :440-447

[5] In Vivo MRI Cell Tracking: Clinical Studies [J].

Bulte, Jeff W. M. .

AMERICAN JOURNAL OF ROENTGENOLOGY, 2009, 193 (02) :314-325

[6] Structure-guided Engineering of Human Thymidine Kinase 2 as a Positron Emission Tomography Reporter Gene for Enhanced Phosphorylation of Non-natural Thymidine Analog Reporter Probe [J].

Campbell, Dean O. ;

Yaghoubi, Shahriar S. ;

Su, Ying ;

Lee, Jason T. ;

Auerbach, Martin S. ;

Herschman, Harvey ;

Satyamurthy, Nagichettiar ;

Czernin, Johannes ;

Lavie, Arnon ;

Radu, Caius G. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (01) :446-454

[7] Stem cell treatment for acute myocardial infarction [J].

Clifford, David M. ;

Fisher, Sheila A. ;

Brunskill, Susan J. ;

Doree, Carolyn ;

Mathur, Anthony ;

Watt, Suzanne ;

Martin-Rendon, Enca .

COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2012, (02)

[8] Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy [J].

de Vries, IJM ;

Lesterhuis, WJ ;

Barentsz, JO ;

Verdijk, P ;

van Krieken, JH ;

Boerman, OC ;

Oyen, WJG ;

Bonenkamp, JJ ;

Boezeman, JB ;

Adema, GJ ;

Bulte, JWM ;

Scheenen, TWJ ;

Punt, CJA ;

Heerschap, A ;

Figdor, CG .

NATURE BIOTECHNOLOGY, 2005, 23 (11) :1407-1413

[9] MRI Reporter Genes [J].

Gilad, Assaf A. ;

Ziv, Keren ;

McMahon, Michael T. ;

van Zijl, Peter C. M. ;

Neeman, Michal ;

Bulte, Jeff W. M. .

JOURNAL OF NUCLEAR MEDICINE, 2008, 49 (12) :1905-1908

[10]

Karussis D, 2010, ARCH NEUROL-CHICAGO, V67, P1187, DOI 10.1001/archneurol.2010.248

← 1 2 3 →