Solubility of pharmaceutical compounds in supercritical carbon dioxide

被引：43

作者：

De Zordi, N. ^{[2
]}

Kikic, I. ^{[1
]}

Moneghini, M. ^{[2
]}

Solinas, D. ^{[1
]}

机构：

[1] Univ Trieste, Dept Ind Engn & Informat Technol, I-34127 Trieste, Italy

[2] Univ Trieste, Dept Chem & Pharmaceut Sci, I-34127 Trieste, Italy

来源：

JOURNAL OF SUPERCRITICAL FLUIDS | 2012年 / 66卷

关键词：

Solubility; Pharmaceutical compounds; Supercritical carbon dioxide; Semi empirical equation; DENSITY-BASED MODELS; RAPID EXPANSION; ANTIINFLAMMATORY DRUGS; STEROID DRUGS; CO2; PREDICTION; PARTICLES; SOLUTE; FLUIDS; ACID;

D O I：

10.1016/j.supflu.2011.09.018

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The solubility of pharmaceutical solid compounds in supercritical carbon dioxide is of great importance in a wide range of applications that include: development of drug delivery systems, powder processing, and precipitation/crystallization processes. This manuscript aims to estimate the solubility behavior of pharmaceutical compounds in supercritical fluids using an activity coefficient model based on linear solvation energy relationships. The parameters of this model were further generalized as a function of the properties of the pharmaceutical compounds. The selected compounds include antioxidants, antibiotics, steroids and anti-inflammatory and their solubility data were collected from literature. This model is able to estimate the solubility of the pharmaceutical compounds in supercritical carbon dioxide within acceptable accuracy for more than 60% of the proposed systems. (c) 2011 Elsevier B.V. All rights reserved.

引用

页码：16 / 22

页数：7

共 68 条

[1] THE USE OF CHARACTERISTIC VOLUMES TO MEASURE CAVITY TERMS IN REVERSED PHASE LIQUID-CHROMATOGRAPHY [J].

ABRAHAM, MH ;

MCGOWAN, JC .

CHROMATOGRAPHIA, 1987, 23 (04) :243-246

[2] Particle production of steroid drugs using supercritical fluid processing [J].

Alessi, P ;

Cortesi, A ;

Kikic, I ;

Foster, NR ;

Macnaughton, SJ ;

Colombo, I .

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 1996, 35 (12) :4718-4726

[3]

[Anonymous], PHARMAALGORITHMS ADM

[4]

[Anonymous], MATL VERS R2010A

[5] Solubilities of two steroid drugs and their mixtures in supercritical carbon dioxide [J].

Asghari-Khiavi, M ;

Yamini, Y ;

Farajzadeh, MA .

JOURNAL OF SUPERCRITICAL FLUIDS, 2004, 30 (02) :111-117

[6] Solubility of the drugs bisacodyl, methimazole, methylparaben, and Iodoquinol in supercritical carbon dioxide [J].

Asghari-Khiavi, M ;

Yamini, Y .

JOURNAL OF CHEMICAL AND ENGINEERING DATA, 2003, 48 (01) :61-65

[7] Investigation on the supercritical carbon dioxide extraction of some polar drugs from spiked matrices and tablets [J].

Bahramifar, N ;

Yamini, Y ;

Shamsipur, M .

JOURNAL OF SUPERCRITICAL FLUIDS, 2005, 35 (03) :205-211

[8] Prediction of the solubility of cholesterol and its esters in supercritical carbon dioxide [J].

Bozorgmehr, Mohammad Reza ;

Housaindokht, Mohammad Reza .

CHEMICAL ENGINEERING & TECHNOLOGY, 2006, 29 (12) :1481-1486

[9] Solubility measurements and modeling of molecules of biological and pharmaceutical interest with supercritical CO2 [J].

Burgos-Solórzano, GI ;

Brennecke, JF ;

Stadtherr, MA .

FLUID PHASE EQUILIBRIA, 2004, 220 (01) :57-69

[10] Prediction of solid-fluid equilibria in supercritical carbon dioxide using linear solvation energy relationships [J].

Bush, D ;

Eckert, CA .

FLUID PHASE EQUILIBRIA, 1998, 150 :479-492

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