Regioselective Ortho-Arylation and Alkenylation of N-Alkyl Benzamides with Boronic Acids via Ruthenium-Catalyzed C-H Bond Activation: An Easy Route to Fluorenones Synthesis

被引：98

作者：

Chinnagolla, Ravi Kiran ^{[1
]}

Jeganmohan, Masilamani ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res, Dept Chem, Pune 411021, Maharashtra, India

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 20期

关键词：

CROSS-COUPLING REACTIONS; AROMATIC KETONES; ARYL HALIDES; PALLADIUM; SP(2); METHOXYBENZAMIDES; 2-ARYLPYRIDINES; ARENES;

D O I：

10.1021/ol3024067

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective ruthenium-catalyzed ortho-arylation of substituted N-alkyl benzamides with aromatic boronic acids in the presence of [{RuCl2(p-cymene)}2], AgSbF6, and Ag2O is described. Further, ortho-arylated N-alkyl benzamides were converted into fluorenones in the presence of trifluoroacetic anhydride and HCl.

引用

页码：5246 / 5249

页数：4

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