The Role of the Vagus Nerve: Modulation of the Inflammatory Reaction in Murine Polymicrobial Sepsis

被引：30

作者：

Kessler, Wolfram ^{[1
]}

Diedrich, Stephan ^{[1
]}

Menges, Pia ^{[1
]}

Ebker, Tobias ^{[2
]}

Nielson, Michael ^{[1
]}

Partecke, Lars Ivo ^{[1
]}

Traeger, Tobias ^{[1
]}

Cziupka, Katharina ^{[1
]}

van der Linde, Julia ^{[1
]}

Puls, Ralf ^{[3
]}

Busemann, Alexandra ^{[1
]}

Heidecke, Claus-Dieter ^{[1
]}

Maier, Stefan ^{[1
]}

机构：

[1] Ernst Moritz Arndt Univ Greifswald, Klin & Poliklin Allgemeine Chirurg Viszeral Thora, D-17475 Greifswald, Germany

[2] Univ Erlangen Nurnberg, Mund Kiefer & Gesichtschirurg Klin, D-91054 Erlangen, Germany

[3] Ernst Moritz Arndt Univ Greifswald, Inst Diagnost Radiol & Neuroradiol, D-17475 Greifswald, Germany

来源：

MEDIATORS OF INFLAMMATION | 2012年 / 2012卷

关键词：

CHOLINERGIC ANTIINFLAMMATORY PATHWAY; VAGAL INNERVATION; ADRENAL-GLAND; ANIMAL-MODELS; SEPTIC SHOCK; RAT-LIVER; IN-VIVO; ACTIVATION; GASTRECTOMY; APOPTOSIS;

D O I：

10.1155/2012/467620

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The particular importance of the vagus nerve for the pathophysiology of peritonitis becomes more and more apparent. In this work we provide evidence for the vagal modulation of inflammation in the murine model of colon ascendens stent peritonitis (CASP). Vagotomy significantly increases mortality in polymicrobial sepsis. This effect is not accounted for by the dilatation of gastric volume following vagotomy. As the stimulation of cholinergic receptors by nicotine has no therapeutic effect, the lack of nicotine is also not the reason for the reduced survival rate. In fact, increased septic mortality is a consequence of the absent modulating influence of the vagus nerve on the immune system: we detected significantly elevated serum corticosterone levels in vagotomised mice 24 h following CASP and a decreased ex vivo TNF-alpha secretion of Kupffer cells upon stimulation with LPS. In conclusion, the vagus nerve has a modulating influence in polymicrobial sepsis by attenuating the immune dysregulation.

引用

页数：9

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