EFFECTS OF NEURITIN ON THE MIGRATION, SENESCENCE AND PROLIFERATION OF HUMAN BONE MARROW MESENCHYMAL STEM CELLS

被引：10

作者：

Wang, Xuhui ^{[1
,2
]}

Liu, Chunyan ^{[1
,2
]}

Xu, Fen ^{[1
,2
]}

Cui, Lijuan ^{[1
,2
]}

Tan, Siwei ^{[3
]}

Chen, Rong ^{[3
]}

Yang, Lei ^{[3
]}

Huang, Jin ^{[1
,2
]}

机构：

[1] Shihezi Univ, Sch Med, Key Lab Xinjiang Endem & Ethn Dis, Shihezi, Xinjiang, Peoples R China

[2] Shihezi Univ, Sch Med, Dept Biochem, Shihezi, Xinjiang, Peoples R China

[3] Hangzhou Normal Univ, Sch Med, Hangzhou, Zhejiang, Peoples R China

来源：

CELLULAR & MOLECULAR BIOLOGY LETTERS | 2015年 / 20卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Neuritin; Migration; Senescence; Proliferation; Cell viability; BMSCs; Non-neuronal cells; Wound scratch; beta-galactosidase; Cell count; CPG15;

D O I：

10.1515/cmble-2015-0026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neuritin is a neurotrophic factor associated with neuroplasticity. Most studies on neuritin focus on the nervous system; however, there has been no comprehensive evaluation of neuritin in non-neuronal cells. In this study, we screened 11 cell lines and found that neuritin was not expressed in bone marrow-derived mesenchymal stem cells (BMSCs). Neuritin-expressing BMSCs were obtained by transfection. In the neuritin-expressing BMSC model, we observed significantly greater cell migration and improved anti-senescence protection, in addition to reduced proliferation and viability. In conclusion, neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells. This study provides a theoretical basis for understanding the function of neuritin.

引用

页码：466 / 474

页数：9

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