Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum

被引：17

作者：

Levin, MJ ^{[1
]}

Weinberg, A

Leary, JJ

Sarisky, RT

机构：

[1] Univ Colorado, Sch Med, Dept Pediat, Infect Dis Sect, Denver, CO USA

[2] SmithKline Beecham Pharmaceut, Mol Virol & Host Dis, Collegeville, PA USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2001年 / 20卷 / 11期

关键词：

antiviral resistance; neonatal herpes simples virus infection;

D O I：

10.1097/00006454-200111000-00021

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.

引用

页码：1094 / 1097

页数：4

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