Macrophages in neovascular age-related macular degeneration: friends or foes?

被引：63
作者：
Skeie, J. M. [1 ,2 ]
Mullins, R. F. [1 ]
机构：
[1] Univ Iowa, Dept Ophthalmol & Visual Sci, Carver Family Ctr Macular Degenerat, Iowa City, IA 52242 USA
[2] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA
来源：
EYE | 2009年 / 23卷 / 04期
关键词：
macular degeneration; macrophage; choroid; angiogenesis; inflammation; animal model; RETINAL-PIGMENT EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; FACTOR-H POLYMORPHISM; C-REACTIVE PROTEIN; CHOROIDAL NEOVASCULARIZATION; BRUCHS MEMBRANE; RISK-FACTORS; VISUAL IMPAIRMENT; ANIMAL-MODEL; DRUSEN;
D O I：
10.1038/eye.2008.206
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this paper, we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.
引用
收藏
页码：747 / 755
页数：9
相关论文
共 86 条
[31]   The genetics of age-related macular degeneration: A review of progress to date [J].
Haddad, Stephen ;
Chen, Clara A. ;
Santangelo, Susan L. ;
Seddon, Johanna M. .
SURVEY OF OPHTHALMOLOGY, 2006, 51 (04) :316-363
[32]   An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration [J].
Hageman, GS ;
Luthert, PJ ;
Chong, NHV ;
Johnson, LV ;
Anderson, DH ;
Mullins, RF .
PROGRESS IN RETINAL AND EYE RESEARCH, 2001, 20 (06) :705-732
[33]   A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration [J].
Hageman, GS ;
Anderson, DH ;
Johnson, LV ;
Hancox, LS ;
Taiber, AJ ;
Hardisty, LI ;
Hageman, JL ;
Stockman, HA ;
Borchardt, JD ;
Gehrs, KM ;
Smith, RJH ;
Silvestri, G ;
Russell, SR ;
Klaver, CCW ;
Barbazetto, I ;
Chang, S ;
Yannuzzi, LA ;
Barile, GR ;
Merriam, JC ;
Smith, RT ;
Olsh, AK ;
Bergeron, J ;
Zernant, J ;
Merriam, JE ;
Gold, B ;
Dean, M ;
Allikmets, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (20) :7227-7232
[34]  
HAGEMAN GS, 2007, ANTIGEN PRESENTING C, P209
[35]   Complement factor H variant increases the risk of age-related macular degeneration [J].
Haines, JL ;
Hauser, MA ;
Schmidt, S ;
Scott, WK ;
Olson, LM ;
Gallins, P ;
Spencer, KL ;
Kwan, SY ;
Noureddine, M ;
Gilbert, JR ;
Schnetz-Boutaud, N ;
Agarwal, A ;
Postel, EA ;
Pericak-Vance, MA .
SCIENCE, 2005, 308 (5720) :419-421
[36]  
Handa JT, 1999, INVEST OPHTH VIS SCI, V40, P775
[37]   Drusen, choroidal neovascularization, and retinal pigment epithelium dysfunction in SOD1-deficient mice: A model of age-related macular degeneration [J].
Imamura, Yutaka ;
Noda, Setsuko ;
Hashizume, Kouhei ;
Shinoda, Kei ;
Yamaguchi, Mineko ;
Uchiyama, Satoshi ;
Shimizu, Takahiko ;
Mizushima, Yutaka ;
Shirasawa, Takuji ;
Tsubota, Kazuo .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (30) :11282-11287
[38]   Advanced glycation end products in age-related macular degeneration [J].
Ishibashi, T ;
Murata, T ;
Hangai, M ;
Nagai, R ;
Horiuchi, S ;
Lopez, PF ;
Hinton, DR ;
Ryan, SJ .
ARCHIVES OF OPHTHALMOLOGY, 1998, 116 (12) :1629-1632
[39]   A potential role for immune complex pathogenesis in drusen formation [J].
Johnson, LV ;
Ozaki, S ;
Staples, MK ;
Erickson, PA ;
Anderson, DH .
EXPERIMENTAL EYE RESEARCH, 2000, 70 (04) :441-449
[40]   Verteporfin therapy in combination with triamcinolone: published studies investigating a potential synergistic effect [J].
Kaiser, PK .
CURRENT MEDICAL RESEARCH AND OPINION, 2005, 21 (05) :705-713
123456789