Macrophages in neovascular age-related macular degeneration: friends or foes?

被引：63

作者：

Skeie, J. M. ^{[1
,2
]}

Mullins, R. F. ^{[1
]}

机构：

[1] Univ Iowa, Dept Ophthalmol & Visual Sci, Carver Family Ctr Macular Degenerat, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Biomed Engn, Iowa City, IA 52242 USA

来源：

EYE | 2009年 / 23卷 / 04期

关键词：

macular degeneration; macrophage; choroid; angiogenesis; inflammation; animal model; RETINAL-PIGMENT EPITHELIUM; ENDOTHELIAL GROWTH-FACTOR; FACTOR-H POLYMORPHISM; C-REACTIVE PROTEIN; CHOROIDAL NEOVASCULARIZATION; BRUCHS MEMBRANE; RISK-FACTORS; VISUAL IMPAIRMENT; ANIMAL-MODEL; DRUSEN;

D O I：

10.1038/eye.2008.206

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The events that lead to choroidal neovascularization in eyes with age-related macular degeneration are poorly understood. One possibility that has been explored in a number of studies is that macrophages can promote neovascular changes. In this paper, we summarize the evidence for inflammation in general and macrophages in particular in pathologic neovascularization, and discuss how the diverse functions of these cells may promote or inhibit macular disease. We also discuss some of the conflicting findings regarding the role of macrophages in experimental choroidal neovascularization in mouse models, and suggest areas for future research.

引用

页码：747 / 755

页数：9

共 86 条

[11] Basal linear deposit and large drusen are specific for early age-related maculopathy [J].