A MicroRNA Encoded by Autographa californica Nucleopolyhedrovirus Regulates Expression of Viral Gene ODV-E25

被引：31

作者：

Zhu, Mengxiao ^{[1
]}

Wang, Jinwen ^{[1
]}

Deng, Riqiang ^{[1
]}

Xiong, Peiwen ^{[1
]}

Liang, Hai ^{[1
]}

Wang, Xunzhang ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 23期

基金：

美国国家科学基金会;

关键词：

RT-PCR; VIRUS; QUANTIFICATION; IDENTIFICATION; PREDICTION; MODEL; REAL; TARGETS;

D O I：

10.1128/JVI.02112-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Baculovirus-encoded microRNAs (miRNAs) have been described in Bombyx mori nucleopolyhedrovirus; however, most of their functions remain unclear. Here we report the identification and characterization of an miRNA encoded by Autographa californica nucleopolyhedrovirus. The identified miRNA, AcMNPV-miR-1, perfectly matched a segment in the coding sequence of the viral gene ODV-E25 and downregulated ODV-E25 mRNA expression, which likely resulted in a reduction of infectious budded virions and accelerated the formation of occlusion-derived virions.

引用

页码：13029 / 13034

页数：6

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