Managing Oral Health in the Context of Antimicrobial Resistance

被引:27
作者
Bessa, Lucinda J. [1 ]
Botelho, Joao [1 ,2 ,3 ]
Machado, Vanessa [1 ,2 ,3 ]
Alves, Ricardo [1 ,2 ]
Mendes, Jose Joao [1 ,2 ,3 ]
机构
[1] Ctr Invest Interdisciplinar Egas Moniz CiiEM, Egas Moniz Cooperat Ensino Super, P-2829511 Caparica, Almada, Portugal
[2] CiiEM, Clin Res Unit CRU, Egas Moniz Cooperat Ensino Super, P-2829511 Caparica, Almada, Portugal
[3] CiiEM, Egas Moniz Cooperat Ensino Super, Evidence Based Hub, P-2829511 Caparica, Almada, Portugal
关键词
antibiotic resistance; antibiotic stewardship; dental practice; oral infections; oral microbiome; oral resistome; ANTIBIOTIC-PROPHYLAXIS; MICROBIOME; PEPTIDES; LACTOBACILLUS; STEWARDSHIP; MANAGEMENT; DENTISTRY; DISEASES;
D O I
10.3390/ijerph192416448
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The oral microbiome plays a major role in shaping oral health/disease state; thus, a main challenge for dental practitioners is to preserve or restore a balanced oral microbiome. Nonetheless, when pathogenic microorganisms install in the oral cavity and are incorporated into the oral biofilm, oral infections, such as gingivitis, dental caries, periodontitis, and peri-implantitis, can arise. Several prophylactic and treatment approaches are available nowadays, but most of them have been antibiotic-based. Given the actual context of antimicrobial resistance (AMR), antibiotic stewardship in dentistry would be a beneficial approach to optimize and avoid inappropriate or even unnecessary antibiotic use, representing a step towards precision medicine. Furthermore, the development of new effective treatment options to replace the need for antibiotics is being pursued, including the application of photodynamic therapy and the use of probiotics. In this review, we highlight the advances undergoing towards a better understanding of the oral microbiome and oral resistome. We also provide an updated overview of how dentists are adapting to better manage the treatment of oral infections given the problem of AMR.
引用
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页数:17
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