Effect of serum cholesterol levels on meta-chlorophenylpiperazine-evoked neuroendocrine responses in healthy subjects

被引：43
|
作者：
Terao, T [1 ]
Yoshimura, R [1 ]
Ohmori, O [1 ]
Takano, T [1 ]
Takahashi, N [1 ]
Iwata, N [1 ]
Suzuki, T [1 ]
Abe, K [1 ]
机构：
[1] UNIV OCCUPAT & ENVIRONM HLTH,DEPT ERGON,YAHATANISHI KU,KITAKYUSHU,FUKUOKA 807,JAPAN
来源：
BIOLOGICAL PSYCHIATRY | 1997年 / 41卷 / 09期
关键词：
cholesterol; serotonin; meta-chlorophenylpiperazine; cortisol; adrenocorticotropic hormone; prolactin;
D O I：
10.1016/S0006-3223(96)00213-2
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study was undertaken to test the hypothesis that serum cholesterol levels might be associated with serotonergic receptor function, The participants were 10 healthy male subjects. After an overnight fast, the subjects received meta-chlorophenylpiperazine (m-CPP) or identical placebo capsules orally in a randomized double-blind, cross-over design. Blood was obtained for measurement of prolactin, cortisol, adrenocorticotropic hormone (ACTH), and cholesterol. There were some significantly positive correlations between serum cholesterol levels and hormonal responses to m-CPP administration, These results suggest that serum cholesterol levels may be positively associated with serotonergic receptor function. (C) 1997 Society of Biological Psychiatry.
引用
收藏
页码：974 / 978
页数：5
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