Convenient copper- and solvent-free Sonogashira-type alkynylation of aryl iodides and bromides using Pd EnCat™

被引：43
作者：
Carpita, Adriano [2 ]
Ribecai, Arianna [1 ]
机构：
[1] GlaxoSmithKline SpA, Chem Dev Dept, I-37135 Verona, Italy
[2] Univ Pisa, Dipartimento Chim & Chim Ind, I-56126 Pisa, Italy
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 02期
关键词：
Pd EnCat (TM); Sonogashira-type alkynylations; Supported catalysts; Copper-free; Solvent less; Microwave; CROSS-COUPLING REACTIONS; POLYUREA-ENCAPSULATED PALLADIUM; AMINE-FREE; CATALYZED-REACTIONS; TERMINAL ALKYNES; SUZUKI-MIYAURA; EFFICIENT; CHLORIDES; PRECATALYSTS; PLATINUM;
D O I：
10.1016/j.tetlet.2008.10.130
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A straightforward methodology is described for the copper- and solvent-free alkynylations of aryl iodides and bromides using 0.1-0.01 mol% of Pd as Pd EnCat (TM) 40 or TPP30. High yielding reactions can be achieved under aerobic conditions for a variety of activated and deactivated aryl iodides: a few examples with aryl bromides are also described. Microwave irradiation is able to enhance yields and rates of these reactions. (c) 2008 Elsevier Ltd. All rights reserved.
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页码：204 / 207
页数：4
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