Synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole

被引：42

作者：

Hernández-Campos, A

Ibarra-Velarde, F

Vera-Montenegro, Y

Rivera-Fernández, N

Castillo, R ^{[1
]}

机构：

[1] Natl Autonomous Univ Mexico, Fac Quim, Dept Farm, Mexico City 04510, DF, Mexico

[2] Natl Autonomous Univ Mexico, Fac Med Vet & Zootecnia, Dept Parasitol, Mexico City 04510, DF, Mexico

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2002年 / 50卷 / 05期

关键词：

fasciolicidal activity; bioisostere; benzimidazole synthesis; Fasciola hepatica;

D O I：

10.1248/cpb.50.649

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and fasciolicidal activity of 5-chloro-2-methylthio-6-(1-naphthyloxy)-1H-benzimidazole (6) is described. Compound 6 showed 100% activity in vitro at 146.70 and 29.34 muM concentrations. It also completely removed 3-d and 10-week-old Fasciola hepatica in sheep at a dose of 15 mg/kg.

引用

页码：649 / 652

页数：4

共 23 条

[1] TREATMENT OF HUMAN CHRONIC FASCIOLIASIS WITH TRICLABENDAZOLE - DRUG EFFICACY AND SEROLOGIC RESPONSE [J].