Early Improvement in Marrow Fibrosis Following Haploidentical Stem Cell Transplantation for a Patient with Myelodysplastic Syndrome with Bone Marrow Fibrosis

被引：1

作者：

Takahashi, Shuichiro ^{[1
]}

Tsumanuma, Riko ^{[2
]}

Aizawa, Keiko ^{[2
]}

Osakabe, Mitsumasa ^{[3
]}

Maeda, Kunihiko ^{[4
]}

Omoto, Ejiro ^{[2
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Hematol, Sapporo, Hokkaido, Japan

[2] Yamagata Prefectural Cent Hosp, Dept Hematol, Yamagata, Japan

[3] Yamagata Prefectural Cent Hosp, Dept Pathol, Yamagata, Japan

[4] Yamagata Prefectural Univ Hlth Sci, Dept Nursing, Yamagata, Japan

来源：

INTERNAL MEDICINE | 2016年 / 55卷 / 22期

关键词：

myelodyspastic syndrome; myelofibrosis; haploidentical hematopoietic stem cell transplantation; post-transplantation cyclophosphamide; MYELOFIBROSIS; CYCLOPHOSPHAMIDE; THERAPY;

D O I：

10.2169/internalmedicine.55.6435

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The prognosis for myelodysplastic syndrome with bone marrow fibrosis (MDS-F) is worse than the prognosis of MDS without fibrosis. Hematopoietic stem cell transplantation (HSCT) is the only curative therapy; however, the indications and the procedures involved in HSCT remain unclear. We herein describe a 69-year-old Japanese man with MDS-F who received haploidentical HSCT and post-transplantation cyclophosphamide. Although the first HSCT resulted in secondary graft failure, the second HSCT using PTCy led to successful engraftment after early improvement in fibrosis. Since the incidence of graft failure is high in myelofibrosis patients, a secondary HSCT using PTCy may be successful if employed.

引用

页码：3351 / 3356

页数：6

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