Synthesis of 4-benzylidene-oxazol-5(4H)-imines, structural analogs of PK11195, under Bischler-Napieralski conditions

被引：3
作者：
Almaraz-Giron, Marco A. [1 ]
Vazquez, Alfredo [1 ]
机构：
[1] Univ Nacl Autonoma Mexico, Dept Quim Organ, Fac Quim, Ciudad Univ, Mexico City 04510, DF, Mexico
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 08期
关键词：
4-Benzylidene-oxazol-5(4H)imines; Bischler-Napieralski reaction; alpha; beta-Unsaturated acid derivatives; Oxazolones; PK11195; ANTIBACTERIAL ACTIVITY;
D O I：
10.1016/j.tetlet.2017.01.047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and convenient one-pot procedure to prepare 4-benzylidene-2-aryl-1,3-oxazol-5(4H)-imines from phenyl pyruvic acid and a series of arylamides, under classical Bischler-Napieralski (B-N) conditions and microwave heating (MW) has been developed. The structures of the prepared compounds were unambiguously assigned through single crystal X-ray diffraction studies. The compounds thus prepared can be used to synthesize bioactive compounds with different molecular architectures. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：785 / 788
页数：4
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