Chemoselective three-component synthesis of homoallylic azides using an FeCl3 catalyst

被引：8

作者：

Pramanik, Suman ^{[1
]}

Ghorai, Prasanta ^{[1
]}

机构：

[1] Indian Inst Sci Educ & Res IISER Bhopal, Dept Chem, Bhopal 462066, India

来源：

RSC ADVANCES | 2013年 / 3卷 / 45期

关键词：

HIGHLY SELECTIVE CONVERSION; ONE-POT PROCEDURE; CLICK-CHEMISTRY; 1,3-DICARBONYL COMPOUNDS; SILYL ETHERS; LEWIS-ACID; ALCOHOLS; CYCLIZATION; IRON; CYCLOADDITION;

D O I：

10.1039/c3ra42821d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A one-pot, three-component synthesis of homoallylic azides from corresponding aldehydes, TMS-allyl, and TMS-N-3 has been developed for the first time using an FeCl3 catalyst. The aromatic and hetero-aromatic aldehydes provided the corresponding homoallylic azides with excellent chemoselectivity. This direct azido-allylation process is also readily scalable (1-28 mmol). The mechanism of the process is proposed. Finally, the selective as well as simultaneous functionalization of homoallylic azides has also been exemplified.

引用

页码：23157 / 23165

页数：9

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