Detection of Infectivity in Blood of Persons with Variant and Sporadic Creutzfeldt-Jakob Disease

被引：63

作者：

Douet, Jean Yves ^{[1
]}

Zafar, Saima ^{[2
]}

Perret-Liaudet, Armand ^{[3
,4
]}

Lacroux, Caroline ^{[1
]}

Lugan, Severine ^{[1
]}

Aron, Naima ^{[1
]}

Cassard, Herve ^{[1
]}

Ponto, Claudia ^{[2
]}

Corbiere, Fabien ^{[1
]}

Torres, Juan Maria ^{[5
]}

Zerr, Inga ^{[2
]}

Andreoletti, Olivier ^{[1
]}

机构：

[1] Ecole Natl Vet Toulouse, Inst Natl Rech Agron, Toulouse, France

[2] Univ Gottingen, Natl Reference Ctr Transmissible Spongiform Encep, D-37073 Gottingen, Germany

[3] Hosp Civils Lyon, Lyon, France

[4] BioRan, Bron, France

[5] Ctr Invest Sanidad Anim, Madrid, Spain

来源：

EMERGING INFECTIOUS DISEASES | 2014年 / 20卷 / 01期

关键词：

SPONGIFORM ENCEPHALOPATHY; PATIENT; MICE; CJD;

D O I：

10.3201/eid2001.130353

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report the presence of infectivity in erythrocytes, leukocytes, and plasma of 1 person with variant Creutzfeldt-Jakob disease and in the plasma of 2 in 4 persons whose tests were positive for sporadic Creutzfeldt-Jakob disease. The measured infectivity levels were comparable to those reported in various animals with transmissible spongiform encephalopathies.

引用

页码：114 / 117

页数：4

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