Synthesis of N-aryl and N-heteroaryl hydroxylamines via partial reduction of nitroarenes with soluble nanoparticle catalysts

被引：10

作者：

Tyler, Jefferson H. ^{[1
]}

Nazari, S. Hadi ^{[1
]}

Patterson, Robert H. ^{[1
]}

Udumula, Venkatareddy ^{[1
]}

Smith, Stacey J. ^{[1
]}

Michaelis, David J. ^{[1
]}

机构：

[1] Brigham Young Univ, Dept Chem & Biochem, Provo, UT 84602 USA

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 01期

关键词：

Hydroxylamine; Nanoparticle; Nitroarene; Chemoselective; Catalysis; AROMATIC NITRO-COMPOUNDS; HIGHLY CHEMOSELECTIVE REDUCTION; METAL NANOPARTICLES; HETEROGENEOUS CATALYSIS; ARYLHYDROXYLAMINES; NITROCOMPOUNDS; HYDROGENATION; SELECTIVITY; AMINATION;

D O I：

10.1016/j.tetlet.2016.11.105

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Polystyrene-supported ruthenium nanoparticles enable the selective hydrazine-mediated reduction of nitroarenes to hydroxylamine products in high yield and selectivity. Key to obtaining the hydroxylamine product in good yield was the use of organic solvents capable of solubilizing the polystyrene-supported nanoparticle catalyst. N-aryl and N-heteroaryl hydroxylamines are generated under exceptionally mild conditions and in the presence of a various easily reduced functional groups. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：82 / 86

页数：5