Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

被引：5
|
作者：
Ueno, Satoshi [1 ,2 ]
Kusaka, Kohtaro [1 ]
Tamada, Yasushi [1 ]
Minaba, Masaomi [1 ]
Zhang, Hong [1 ]
Wang, Pi-Chao [2 ]
Kato, Yusuke [1 ]
机构：
[1] Natl Inst Agrobiol Sci, Div Insect Sci, Tsukuba, Ibaraki 3058634, Japan
[2] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 12期
基金：
日本学术振兴会;
关键词：
cecropin; antimicrobial peptide; precursor; innate immunity; nematode;
D O I：
10.1271/bbb.80397
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.
引用
收藏
页码：3281 / 3284
页数：4
相关论文
共 50 条
  • [31] In vitro and in vivo antimicrobial activity of a synthetic peptide derived from the C-terminal region of human chemokine CCL13 against Pseudomonas aeruginosa
    Cossio-Ayala, Mayte
    Dominguez-Lopez, Mariana
    Mendez-Enriquez, Erika
    del Carmen Portillo-Tellez, Maria
    Garcia-Hernandez, Enrique
    PEPTIDES, 2017, 94 : 49 - 55
  • [32] High-level soluble expression of the functional peptide derived from the C-terminal domain of the sea cucumber lysozyme and analysis of its antimicrobial activity
    Cong, Lina
    Liang, Wenjing
    Wu, Yao
    Li, Cheng
    Chang, Yihai
    Dong, Liang
    Song, Wanlin
    Ma, Jun
    ELECTRONIC JOURNAL OF BIOTECHNOLOGY, 2014, 17 (06): : 280 - 286
  • [33] Identification and characterization of the antimicrobial peptide corresponding to C-terminal β-sheet domain of tenecin 1, an antibacterial protein of larvae of Tenebrio molitor
    Biochemical Journal, 1998, 334 (pt 1): : 99 - 105
  • [34] Identification and characterization of the antimicrobial peptide corresponding to C-terminal β-sheet domain of tenecin 1, an antibacterial protein of larvae of Tenebrio molitor
    Lee, KH
    Hong, SY
    Oh, JE
    Kwon, MY
    Yoon, JH
    Lee, JH
    Lees, BL
    Moon, HM
    BIOCHEMICAL JOURNAL, 1998, 334 : 99 - 105
  • [35] Rab4 C-terminal peptide inhibits insulin-induced glucose transport in rat adipocytes.
    Shibata, H
    Omata, W
    Tanaka, S
    Kojima, I
    DIABETES, 1996, 45 : 569 - 569
  • [36] Antiviral activity of fullerene C60 nanocrystals modified with derivatives of anionic antimicrobial peptide maximin H5
    Simona Dostalova
    Amitava Moulick
    Vedran Milosavljevic
    Roman Guran
    Marketa Kominkova
    Kristyna Cihalova
    Zbynek Heger
    Lucie Blazkova
    Pavel Kopel
    David Hynek
    Marketa Vaculovicova
    Vojtech Adam
    Rene Kizek
    Monatshefte für Chemie - Chemical Monthly, 2016, 147 : 905 - 918
  • [37] Antiviral activity of fullerene C60 nanocrystals modified with derivatives of anionic antimicrobial peptide maximin H5
    Dostalova, Simona
    Moulick, Amitava
    Milosavljevic, Vedran
    Guran, Roman
    Kominkova, Marketa
    Cihalova, Kristyna
    Heger, Zbynek
    Blazkova, Lucie
    Kopel, Pavel
    Hynek, David
    Vaculovicova, Marketa
    Adam, Vojtech
    Kizek, Rene
    MONATSHEFTE FUR CHEMIE, 2016, 147 (05): : 905 - 918
  • [38] Effect of C-terminal and N-terminal dimerization and alanine scan on antibacterial activity of the analogs of the peptide p-BthTX-I
    Santos Filho, Norival Alves
    Righetto, Gabriela Marinho
    Piccoli, Julia Pinto
    Teizen Almeida, Larissa Mathias
    Leal, Thaina Cristina
    Baratella da Cunha Camargo, Ilana Lopes
    Cilli, Eduardo Maffud
    BIOPHYSICAL REVIEWS, 2021, 13 (06) : 1354 - 1355
  • [39] Effect of C-terminal and N-terminal dimerization and alanine scanning on antibacterial activity of the analogs of the peptide p-BthTX-I
    Santos-Filho, Norival Alves
    Righetto, Gabriela Marinho
    Pereira, Marina Rodrigues
    Piccoli, Julia Pinto
    Teizen Almeida, Larissa Mathias
    Leal, Thaina Cristina
    Baratella Cunha Camargo, Ilana Lopes
    Cilli, Eduardo Maffud
    PEPTIDE SCIENCE, 2022, 114 (02)
  • [40] Three-dimensional structure in lipid micelles of the pediocin-like antimicrobial peptide sakacin P and a sakacin P variant that is structurally stabilized by an inserted C-terminal disulfide bridges
    Uteng, M
    Hauge, HH
    Markwick, PRL
    Fimland, G
    Mantzilas, D
    Nissen-Meyer, J
    Muhle-Goll, C
    BIOCHEMISTRY, 2003, 42 (39) : 11417 - 11426
12345