Anionic C-Terminal Proregion of Nematode Antimicrobial Peptide Cecropin P4 Precursor Inhibits Antimicrobial Activity of the Mature Peptide

被引：5
|
作者：
Ueno, Satoshi [1 ,2 ]
Kusaka, Kohtaro [1 ]
Tamada, Yasushi [1 ]
Minaba, Masaomi [1 ]
Zhang, Hong [1 ]
Wang, Pi-Chao [2 ]
Kato, Yusuke [1 ]
机构：
[1] Natl Inst Agrobiol Sci, Div Insect Sci, Tsukuba, Ibaraki 3058634, Japan
[2] Univ Tsukuba, Grad Sch Life & Environm Sci, Tsukuba, Ibaraki 3058572, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2008年 / 72卷 / 12期
基金：
日本学术振兴会;
关键词：
cecropin; antimicrobial peptide; precursor; innate immunity; nematode;
D O I：
10.1271/bbb.80397
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recently, an anionic proregion was found to be conserved at the C terminus of the antimicrobial peptide, nematode cecropin. Our results suggest that the antimicrobial activity of mature peptide is suppressed by the proregion in its precursor and is released from inhibition after processing. Inhibition is not likely to be due to direct suppression of membrane disruption.
引用
收藏
页码：3281 / 3284
页数：4
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