Distinct Roles of Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral Interferon Regulatory Factors in Inflammatory Response and Cancer

被引：48

作者：

Baresova, Petra ^{[1
]}

Pitha, Paula M. ^{[2
]}

Lubyova, Barbora ^{[1
]}

机构：

[1] Charles Univ Prague, Fac Med 1, Inst Microbiol & Immunol, Prague, Czech Republic

[2] Johns Hopkins Univ, Dept Biol, Baltimore, MD 21218 USA

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 17期

关键词：

PML ONCOGENIC DOMAINS; CELL-CYCLE ARREST; NF-KAPPA-B; FOXO TRANSCRIPTION FACTORS; ACTIVATED PROTEIN-KINASE; P53; TUMOR-SUPPRESSOR; TGF-BETA; C-MYC; GENE-EXPRESSION; FACTOR FAMILY;

D O I：

10.1128/JVI.03315-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiologic agent associated with Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). Similar to other herpesviruses, KSHV has two life cycles, latency and lytic replication. In latency, the KSHV genome persists as a circular episome in the nucleus of the host cell and only a few viral genes are expressed. In this review, we focus on oncogenic, antiapoptotic, and immunomodulating properties of KSHV-encoded homologues of cellular interferon regulatory factors (IRFs)-viral IRF1 (vIRF1) to vIRF4-and their possible role in the KSHV-mediated antiviral response, apoptosis, and oncogenicity.

引用

页码：9398 / 9410

页数：13

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