Population Structure and Antimicrobial Susceptibility of Both Nonpersistent and Persistent Pseudomonas aeruginosa Isolates Recovered from Cystic Fibrosis Patients

被引:26
作者
Fernandez-Olmos, Ana [1 ,2 ,3 ]
Garcia-Castillo, Mara [1 ,2 ,3 ]
Maria Alba, Jose [1 ,2 ,3 ,4 ]
Isabel Morosini, Mara [1 ,2 ,3 ,5 ]
Lamas, Adelaida [6 ]
Romero, Beatriz [1 ,2 ,3 ]
Carlos Galan, Juan [1 ,2 ,3 ,5 ]
del Campo, Rosa [1 ,2 ,3 ,5 ]
Canton, Rafael [1 ,2 ,3 ,5 ]
机构
[1] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
[2] Hosp Univ Ramon y Cajal, Unidad Resistencia Antibiot & Virulencia Bacteria, CSIC, Madrid, Spain
[3] IRYCIS, Madrid, Spain
[4] CIBERESP, Madrid, Spain
[5] Inst Salud Carlos III, Spanish Network Res Infect Dis REIPI, Madrid, Spain
[6] Hosp Univ Ramon y Cajal, Unidad Fibrosis Quist, Madrid, Spain
关键词
FIELD GEL-ELECTROPHORESIS; SPREAD; STRAIN;
D O I
10.1128/JCM.00802-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Seventy-six Pseudomonas aeruginosa isolates recovered from chronically (n = 18) and nonchronically (n = 18) colonized cystic fibrosis (CF) patients (2002 to 2009) were grouped in separate polyclonal populations. International CF epidemic clones were not identified, but the high-risk clone ST274, also found circulating in Spanish hospitals, was present. Persistent isolates were more resistant to antibiotics than nonpersistent isolates.
引用
收藏
页码:2761 / 2765
页数:5
相关论文
共 19 条
[1]   Genetic Markers of Widespread Extensively Drug-Resistant Pseudomonas aeruginosa High-Risk Clones [J].
Cabot, Gabriel ;
Ocampo-Sosa, Alain A. ;
Angeles Dominguez, M. ;
Gago, Juan F. ;
Juan, Carlos ;
Tubau, Fe ;
Rodriguez, Cristina ;
Moya, Bartolome ;
Pena, Carmen ;
Martinez-Martinez, Luis ;
Olivera, Antonio .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (12) :6349-6357
[2]   Antimicrobial therapy for pulmonary pathogenic colonisation and infection by Pseudomonas aeruginosa in cystic fibrosis patients [J].
Cantón, R ;
Cobos, N ;
de Gracia, J ;
Baquero, F ;
Honorato, J ;
Gartner, S ;
Alvarez, A ;
Salcedo, A ;
Oliver, A ;
García-Quetglas, E .
CLINICAL MICROBIOLOGY AND INFECTION, 2005, 11 (09) :690-703
[3]   Spread of beta-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic [J].
Cheng, K ;
Smyth, RL ;
Govan, JRW ;
Doherty, C ;
Winstanley, C ;
Denning, N ;
Heaf, DP ;
vanSaene, H ;
Hart, CA .
LANCET, 1996, 348 (9028) :639-642
[4]   Bayesian semi-supervised classification of bacterial samples using MLST databases [J].
Cheng, Lu ;
Connor, Thomas R. ;
Aanensen, David M. ;
Spratt, Brian G. ;
Corander, Jukka .
BMC BIOINFORMATICS, 2011, 12
[5]  
Clinical and Laboratory Standards Institute, 2012, M100S22 CLSI S
[6]   Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective [J].
Folkesson, Anders ;
Jelsbak, Lars ;
Yang, Lei ;
Johansen, Helle Krogh ;
Ciofu, Oana ;
Hoiby, Niels ;
Molin, Soren .
NATURE REVIEWS MICROBIOLOGY, 2012, 10 (12) :841-851
[7]   Emergence of a mutL Mutation Causing Multilocus Sequence Typing-Pulsed-Field Gel Electrophoresis Discrepancy among Pseudomonas aeruginosa Isolates from a Cystic Fibrosis Patient [J].
Garcia-Castillo, Maria ;
Maiz, Luis ;
Morosini, Maria-Isabel ;
Rodriguez-Banos, Mercedes ;
Suarez, Lucrecia ;
Fernandez-Olmos, Ana ;
Baquero, Fernando ;
Canton, Rafael ;
del Campo, Rosa .
JOURNAL OF CLINICAL MICROBIOLOGY, 2012, 50 (05) :1777-1778
[8]   Wide Dispersion of ST175 Clone despite High Genetic Diversity of Carbapenem-Nonsusceptible Pseudomonas aeruginosa Clinical Strains in 16 Spanish Hospitals [J].
Garcia-Castillo, Maria ;
del Campo, Rosa ;
Isabel Morosini, Maria ;
Riera, Elena ;
Cabot, Gabriel ;
Willems, Rob ;
van Mansfeld, Rosa ;
Oliver, Antonio ;
Canton, Rafael .
JOURNAL OF CLINICAL MICROBIOLOGY, 2011, 49 (08) :2905-2910
[9]   Spread of colistin resistant non-mucoid Pseudomonas aeruginosa among chronically infected Danish cystic fibrosis patients [J].
Johansen, Helle Krogh ;
Moskowitz, Samuel M. ;
Ciofu, Oana ;
Pressler, Tacjana ;
Hoiby, Niels .
JOURNAL OF CYSTIC FIBROSIS, 2008, 7 (05) :391-397
[10]   Spread of a multiresistant strain of Pseudomonas aeruginosa in an adult cystic fibrosis clinic [J].
Jones, AM ;
Govan, JRW ;
Doherty, CJ ;
Dodd, ME ;
Isalska, BJ ;
Stanbridge, TN ;
Webb, AK .
LANCET, 2001, 358 (9281) :557-558