Synthetic oligonucleotide combinatorial libraries - Tools for studying nucleic acid interactions

被引：7
|
作者：
Seliger, H [1 ]
Bader, R [1 ]
Hinz, M [1 ]
Rotte, B [1 ]
Astriab, A [1 ]
Markiewicz, M [1 ]
Markiewicz, WT [1 ]
机构：
[1] POLISH ACAD SCI,INST BIOORGAN CHEM,PL-61704 POZNAN,POLAND
来源：
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 5-6期
关键词：
D O I：
10.1080/07328319708002937
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This paper gives an overview of methods available for, and difficulties encountered in the preparation of synthetic oligonucleotide combinatorial libraries. The application of libraries immobilized to high-load beds to the screening of specific two-component (nucleic acid / nucleic acid) and three-component (ds nucleic acid/protein) interactions is described. The effector oligonucleotides immobilized to a single bead are identified by direct Maxam-Gilbert sequencing.
引用
收藏
页码：703 / 710
页数：8
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