Vilsmeier Reaction of Enaminones: Efficient Synthesis of Halogenated Pyridin-2(1H)-ones

被引：57

作者：

Zhang, Rui ^{[1
]}

Zhang, Dingyuan ^{[1
]}

Guo, Yongli ^{[1
]}

Zhou, Guangyuan ^{[1
]}

Jiang, Zijiang ^{[1
]}

Dong, Dewen ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 73卷 / 23期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1021/jo801959j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and efficient one-pot synthesis of halogenated pyridin-2(1H)-ones from a series of readily available enaminones under Vilsmeier conditions is described, and a mechanism involving sequential halogenation, formylation, and intramolecular nucleophilic cyclization is proposed.

引用

页码：9504 / 9507

页数：4

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