Two coupled enzymes perform in parallel the 'AND' and 'InhibAND' logic gate operations

被引：59
作者：
Baron, R [1 ]
Lioubashevski, O [1 ]
Katz, E [1 ]
Niazov, T [1 ]
Willner, I [1 ]
机构：
[1] Hebrew Univ Jerusalem, Inst Chem, IL-91904 Jerusalem, Israel
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2006年 / 4卷 / 06期
关键词：
D O I：
10.1039/b518205k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The coupled activation of two enzymes: glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), is used to construct the parallel-operating AND and InhibAND logic gates. The added substrates for the respective enzymes, glucose and H2O2, act as the gate inputs, while the biocatalytically generated NADH and gluconic acid provide the output signals that follow the operations of the gates. The two gates are generated in the same vial, thus allowing the logic operations to take place in parallel, and the simultaneous readout of the functions of the gates.
引用
收藏
页码：989 / 991
页数：3
相关论文
共 30 条
  • [1] Molecule-based photonically switched half-adder
    Andréasson, J
    Kodis, G
    Terazono, Y
    Liddell, PA
    Bandyopadhyay, S
    Mitchell, RH
    Moore, TA
    Moore, AL
    Gust, D
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (49) : 15926 - 15927
  • [2] Boolean logic functions of a synthetic peptide network
    Ashkenasy, G
    Ghadiri, MR
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2004, 126 (36) : 11140 - 11141
  • [3] Oxygen metabolism in plant/bacteria interactions: Effect of DPI on the pseudo-NAD(P)H oxidase activity of peroxidase
    Baker, CJ
    Deahl, K
    Domek, J
    Orlandi, EW
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 252 (02) : 461 - 464
  • [4] Programmable and autonomous computing machine made of biomolecules
    Benenson, Y
    Paz-Elizur, T
    Adar, R
    Keinan, E
    Livneh, Z
    Shapiro, E
    [J]. NATURE, 2001, 414 (6862) : 430 - 434
  • [5] Switching between molecular switch types by module rearrangement:: Ca2+-enabled, H+-driven 'Off-On-Off', H+-driven YES and PASS 0 as well as H+, Ca2+-driven AND logic operations
    Callan, JF
    de Silva, AP
    McClenaghan, ND
    [J]. CHEMICAL COMMUNICATIONS, 2004, (18) : 2048 - 2049
  • [6] Molecular photoionic and logic gates with bright fluorescence and ''off-on'' digital action
    de Silva, AP
    Gunaratne, HQN
    McCoy, CP
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1997, 119 (33) : 7891 - 7892
  • [7] Molecular computation - Molecular logic gets loaded
    De Silva, AP
    [J]. NATURE MATERIALS, 2005, 4 (01) : 15 - 16
  • [8] de Silva AP, 2000, J AM CHEM SOC, V122, P3965
  • [9] de Silva AP, 2002, CHEM-EUR J, V8, P4935, DOI 10.1002/1521-3765(20021104)8:21<4935::AID-CHEM4935>3.0.CO
  • [10] 2-2
123