All Roads Lead to the miRNome: miRNAs Have a Central Role in the Molecular Pathophysiology of Psychiatric Disorders

被引：54

作者：

O'Connor, Richard M. ^{[1
]}

Gururajan, Anand ^{[2
]}

Dinan, Timothy G. ^{[3
,4
]}

Kenny, Paul J. ^{[1
]}

Cryan, John F. ^{[2
,4
]}

机构：

[1] Mt Sinai Hosp, Icahn Sch Med, Dept Neurosci, New York, NY 10029 USA

[2] Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

[3] Univ Coll Cork, Dept Psychiat, Cork, Ireland

[4] Univ Coll Cork, APC Microbiome Inst, Cork, Ireland

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2016年 / 37卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

DEEP BRAIN-STIMULATION; MAJOR DEPRESSION; POSTTRANSCRIPTIONAL REGULATION; MICRORNA-132; DYSREGULATION; PREFRONTAL CORTEX; STRESS RESILIENCE; BDNF EXPRESSION; P-GLYCOPROTEIN; COCAINE INTAKE; SCHIZOPHRENIA;

D O I：

10.1016/j.tips.2016.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Current treatment strategies for psychiatric disorders remain inadequate. Impeding development of novel therapeutics is our incomplete knowledge of the molecular pathophysiology underlying these disorders. Changes to miRNA function and expression are increasingly being associated with pathological behavioral states. Furthermore, the prospect of using of miRNA expression profiles (the miRNome) as objective psychiatric diagnosis tools is gaining traction. In this review, we focus on recent findings surrounding the link between miRNA function and psychiatric disorders, and outline some of the key challenges that will need to be overcome if the therapeutic potential of these molecular effectors is to be fully realized.

引用

页码：1029 / 1044

页数：16

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