Tetrahydroxystilbene glucoside antagonizes age-related α-synuclein overexpression in the hippocampus of APP transgenic mouse model of Alzheimer's disease

被引：42
作者：
Zhang, Lan [1 ]
Yu, Shun [2 ]
Zhang, Ruyi [1 ]
Xing, Ying [1 ]
Li, Yaohua [2 ]
Li, Lin [1 ]
机构：
[1] Capital Med Univ, Xuanwu Hosp, Key Lab Neurodegenerat Dis, Dept Pharmacol,Minist Educ, Beijing 100053, Peoples R China
[2] Capital Med Univ, Xuanwu Hosp, Dept Neurobiol, Beijing 100053, Peoples R China
来源：
RESTORATIVE NEUROLOGY AND NEUROSCIENCE | 2013年 / 31卷 / 01期
基金：
中国国家自然科学基金; 北京市自然科学基金;
关键词：
2,3,5,4 '-tetrahydroxy stilbene-2-O-beta-D-glucoside; Polygonum multiflorum; APPV717I transgenic mice; alpha-synuclein; hippocampus; Alzheimer's disease; AMYLOID PRECURSOR PROTEIN; BETA-PROTEIN; MICE; PATHOLOGY; ACCUMULATION; PARKINSONS; EXPRESSION; DEPOSITION; OXIDATION; DEMENTIA;
D O I：
10.3233/RNN-120260
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Purpose: To investigate the mRNA and protein alterations of alpha-synuclein in the brain of Alzheimer's disease-like mouse model at the different ages, and to evaluate the effects of 2,3,5,4'-tetrahydroxy stilbene-2-O-beta-D-glucoside (TSG) on alpha-synuclein expression. Methods: TSG (120 or 240 mu mol kg(-1)d(-1)) was intragastrically administered to APPV717I transgenic (Tg) mice at 4- or 10-month-old for 6 months. Results: mRNA expression of alpha-synuclein increased in hippocampus in 4 month to 16 month old Tg mice compared with age-matched control. alpha-synuclein protein expression in hippocampus also increased in 4 month to 16 month old Tg mice significantly. Significant down-regulation of alpha-synuclein mRNA and protein expression in hippocampus was found after treatment of TSG for 6 months in both 10- and 16-month-old Tg mice. Production of dimer and tetramer of alpha-synuclein protein in Tg mice was inhibited after treatment with TSG. Conclusions: The expression and aggregation of alpha-synuclein was age-dependently increased in Tg mice. TSG not only prevents over-expression of alpha-synuclein at an early stage, but also reverses the increased expression of alpha-synuclein and inhibits the aggregation at the late stage of Tg mice. TSG may have potential to the prevention and treatment of Alzheimer's diseases.
引用
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页码：41 / 52
页数：12
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