An Amphiphilic Perylene Imido Diester for Selective Cellular Imaging

被引：72

作者：

Heek, Timm ^{[1
]}

Nikolaus, Joerg ^{[2
]}

Schwarzer, Roland ^{[2
]}

Fasting, Carlo ^{[1
]}

Welker, Pia ^{[3
]}

Licha, Kai ^{[3
]}

Herrmann, Andreas ^{[2
]}

Haag, Rainer ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem, D-14195 Berlin, Germany

[2] Humboldt Univ, Inst Biol Mol Biophys, D-10115 Berlin, Germany

[3] Mivenion GmbH, D-10115 Berlin, Germany

来源：

BIOCONJUGATE CHEMISTRY | 2013年 / 24卷 / 02期

关键词：

SPECTROSCOPIC PROPERTIES; PLASMA-MEMBRANE; PI-STACKS; FLUORESCENCE; DYES; TRANSPORT; PROBES; FLUOROPHORES; AGGREGATION; DENDRONS;

D O I：

10.1021/bc3005655

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new amphiphilic membrane marker based on a water-soluble dendritic polyglycerol perylene imido diallcylester has been designed, synthesized, and its optical properties characterized. In water it forms fluorescently quenched micellar self-aggregates, but when incorporated into a lipophilic environment, it monomerizes, and the highly fluorescent properties of the perylene core are recovered. These properties make it an ideal candidate for the imaging of artificial and cellular membranes as demonstrated by biophysical studies.

引用

页码：153 / 158

页数：6

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