Antioxidant and radical scavenging activities of some norcantharidin and bridged perhydroisoindole derivatives

被引：11
|
作者：
Peksel, Aysegul [1 ]
Celik, Cumali [1 ,2 ]
Ocal, Nuket [1 ]
Yanardag, Refiye [3 ]
机构：
[1] Yildiz Tech Univ, Fac Arts & Sci, Dept Chem, TR-34210 Istanbul, Turkey
[2] Yalova Univ, Community Coll, TR-77100 Yalova, Turkey
[3] Istanbul Univ, Fac Engn, Dept Chem, TR-34320 Istanbul, Turkey
来源：
JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | 2013年 / 78卷 / 01期
关键词：
norcantharidin; bridged perhydroisoindole; reducing power; super-oxide anion radical; 1,3-DIPOLAR CYCLOADDITION REACTION; SUBSTITUTED CYCLIC IMIDES; ANTICANCER; EXTRACTS;
D O I：
10.2298/JSC120123036P
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of norcantharidin and bridged perhydroisoindole derivatives were evaluated for their antioxidant and radical scavenging activities. Different in vitro methodologies, such as total reducing power, 1,1-diphenyl-2-picryl-hydrazil (DPPH center dot) free radical scavenging, superoxide anion radical scavenging and metal chelating activities were used. Among the 11 tested compounds, 7 compounds showed potent reducing power activity and 7 compounds showed potent superoxide anion radical scavenging activity. All the tested compounds exhibited potent free radical scavenging ability. The results showed that the synthesized compounds have effective antioxidant power.
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收藏
页码：15 / 25
页数：11
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