One-Pot, Two-Step Conversion of Aldehydes to Phosphonyl- and Sulfonylpyrazoles Using Bestmann-Ohira Reagent

被引：63
作者：
Kumar, Rahul [1 ]
Verma, Deepti [1 ]
Mobin, Shaikh M. [2 ]
Namboothiri, Irishi N. N. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
[2] Indian Inst Technol, Natl Single Crystal Xray Diffract Facil, Bombay 400076, Maharashtra, India
来源：
ORGANIC LETTERS | 2012年 / 14卷 / 16期
关键词：
BASE-MEDIATED REACTION; REGIOSELECTIVE SYNTHESIS; DIAZOCARBONYL COMPOUNDS; PYRAZOLE; CYCLOADDITION; DERIVATIVES; CHEMISTRY; DIAZOALKANES; NITROALKENES; COMPLEXES;
D O I：
10.1021/ol301695e
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A one-pot, two-step, three-component method for the conversion of commercially available aldehydes to phosphonylpyrazoles has been developed, demonstrating, for the first time, the dual reactivity of the Bestmann-Ohira reagent (BOR) in a single-pot transformation. This method, extended to the synthesis of sulfonylpyrazoles by employing BOR in the first step and a diazomethyl sulfone in the second step, is complementary, with regard to regioselectivity, to the previous methods for the synthesis of such functionalized pyrazoles.
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收藏
页码：4070 / 4073
页数：4
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