Remyelination-Promoting Inflammation: Novel Role for MyD88 Signaling in Microglia/Macrophages

被引：1

作者：

Murugaiyan, Gopal ^{[1
,2
]}

Fujiwara, Mai ^{[1
,2
]}

Garo, Lucien P. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Dept Neurol, Ann Romney Ctr Neurol Dis, 75 Francis St, Boston, MA 02115 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

来源：

TRENDS IN NEUROSCIENCES | 2020年 / 43卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.tins.2020.04.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Inflammation in the central nervous system (CNS) has been linked to demyelination and remyelination. Using zebrafish and mouse models of demyelination and remyelination, Cunha et al. now describe a novel role for myeloid differentiation factor 88 (MyD88) signaling in supporting remyelination by promoting myeloid cell-mediated inflammatory responses via TNF-alpha, which are essential for phagocytic myelin debris clearance and for oligodendrogenesis.

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收藏

页码：455 / 457

页数：3

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