Evaluation of bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model

被引：5
作者：
Nisbet, H. Ozlem [1 ]
Ozak, Ahmet [1 ]
Yardimci, Cenk [1 ]
Nisbet, Cevat [2 ]
Yarim, Murat [3 ]
Bayrak, I. Koray [4 ]
Sirin, Y. Sinan [1 ]
机构：
[1] Ondokuz Mayis Univ, Fac Vet Med, Dept Surg, TR-55139 Kurupelit, Samsun, Turkey
[2] Ondokuz Mayis Univ, Fac Vet Med, Dept Biochem, TR-55139 Kurupelit, Samsun, Turkey
[3] Ondokuz Mayis Univ, Fac Vet Med, Dept Pathol, TR-55139 Kurupelit, Samsun, Turkey
[4] Ondokuz Mayis Univ, Fac Vet Med, Dept Radiol, TR-55139 Kurupelit, Samsun, Turkey
来源：
RESEARCH IN VETERINARY SCIENCE | 2012年 / 93卷 / 01期
关键词：
Bee venom; Hyaluronic acid; Experimental; Osteoarthritis; Radiography; Magnetic resonance; Histopathology; Rabbit; ARTICULAR-CARTILAGE THICKNESS; RESONANCE-IMAGING MRI; KNEE OSTEOARTHRITIS; MOLECULAR-WEIGHT; ARTHRITIS; MELITTIN; EDEMA; INJECTIONS; RATS; PAIN;
D O I：
10.1016/j.rvsc.2011.08.007
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of this study was to investigate bee venom and hyaluronic acid in the intra-articular treatment of osteoarthritis in an experimental rabbit model. Forty-five rabbits were used and they were randomly divided into three groups (BVI, MI, and HA) and each group was divided to two subgroups to evaluate the radiologic, magnetic resonance imaging, histopathologic, and biochemical evaluation in post treatment second week (a) and twelfth week (b). Radiologically, a significant difference was observed in the HA group (P < 0.05). The MRI evaluation of at any time in group BVI(b) was found to be different. No significant differences were seen between the groups, biochemically. Histopathologically, cellularity, and orthochromasia was evident with Safranin-O in the BVI(b) and BVII(a); adhesions were seen in the BVII(a) group and clustering of chondrocyte in the HA(b) group were found to be different. Consequently, intra-articular application of HA and BV for experimental model of osteoarthritis has no significant influence upon recovery after therapy. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：488 / 493
页数：6
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