Potential Renoprotective Agents through Inhibiting CTGF/CCN2 in Diabetic Nephropathy

被引：20

作者：

Wang, Songyan ^{[1
,2
]}

Li, Bing ^{[2
]}

Li, Chunguang ^{[3
]}

Cui, Wenpeng ^{[1
]}

Miao, Lining ^{[1
]}

机构：

[1] Jilin Univ, Hosp 2, Dept Nephrol, Changchun 130041, Peoples R China

[2] Jilin Prov Peoples Hosp, Dept Nephrol, Changchun 130021, Peoples R China

[3] 2nd Hosp Changchun, Dept Urol, Changchun 130061, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

TISSUE-GROWTH-FACTOR; GLUCAGON-LIKE PEPTIDE-1; EPITHELIAL-MESENCHYMAL TRANSITION; (PRO)RENIN RECEPTOR CONTRIBUTES; CTGF MONOCLONAL-ANTIBODY; FACTOR-KAPPA-B; MESANGIAL CELLS; MYCOPHENOLATE-MOFETIL; FACTOR INDUCTION; PIVOTAL ROLE;

D O I：

10.1155/2015/962383

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease (ESRD). The development and progression of DN might involve multiple factors. Connective tissue growth factor (CCN2, originally known as CTGF) is the one which plays a pivotal role. Therefore, increasing attention is being paid to CCN2 as a potential therapeutic target for DN. Up to date, there are also many drugs or agents which have been shown for their protective effects against DN via different mechanisms. In this review, we only focus on the potential renoprotective therapeutic agents which can specifically abolish CCN2 expression or nonspecifically inhibit CCN2 expression for retarding the development and progression of DN.

引用

页数：11

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